Cytostatic Hyperthermic Isolated Limb Perfusion (HILP) in VFN (General Faculty Hospital in Prague)
Authors:
M. Špaček; P. Mitáš; L. Lacina 1; I. Krajsová 1; G. Hodková; M. Salmay; R. Špunda; L. Brlicová; J. Lindner
Authors place of work:
II. chirurgická klinika, kardiovaskulární chirurgie, 1. LF UK a VFN v Praze
; Dermatovenerologická klinika, 1. LF UK a VFN v Praze
1
Published in the journal:
Rozhl. Chir., 2011, roč. 90, č. 1, s. 62-66.
Category:
Monothematic special - Original
Summary
Hyperthermic isolated limb perfusion (HILP) is a standardized method of treatment in selected patiens with in-transient locoregional recurence/methastasis of melanoma or, some other soft tissue tumors (incl. sarcoma etc.) Authors present history and current status of this treatment modality in General University Hospital in Prague. During one year period (7/2009–6/2010) 10 patients were indicated for this procedure. We performed 13 procedures (3x redo), 11 in lower extremity and 2 in upper extremity. There was no serious complication in this cohort of patiens. Multidisciplinar approach is indicated in melanoma patiens care.
Key words:
regional hypertermic perfusion – melanoma – in-transit metastases – melphalan – TNF
Zdroje
1. Noorda, E., Vrouenraets, B., Nieweg, O., et al. Isolated limb perfusion for unresectable melanoma of the extremities. Arch. Surg., 2004: 139: 1237–1242.
2. Krementz, E. T. Regional perfusion. Cancer, 57, 1986: 416–432.
3. Lichtenberg, J. Izolovaná perfuze cytostatiky v léčbě zhoubných nádorů končetin. Prakt. Lék., 42, 1962, p. 781–783.
4. Bříza, J., Lichtenberg, J., Teršíp, K., Tošovský, J. Naše zkušenosti s izolovanou regionální hypertermií perfuzí cytostatiky u končetinových nádorů. Rozhl. Chir., 68, 1989, No. 2, p. 113–116.
5. Grunhagen, D., van Etten, B., Brunstein, F., et al. Efficacy of repeat isolated limb perfusion with tumor necrosis factor alpha and melphalan for multiple in-transit metastases in patiens with prior isolated limb perfusion silure. Ann. Surg. Oncol., 12(8): 609–615.
6. Wieberdink, J., et al. Dosimetry in isolation perfusion of the limbs by assesment of perfused tissue volume and grading of toxic tissue reaction. Eur. J. Cancer Clin. Oncol., 1982: 18: 905–910.
7. Noorda, E. M., et al. Isolated limb perfusion for unresectable melanoma of the extremities. Arch. Surg., 2004: 139: 1237–1242.
8. Overgaard, J., Gonzalez, G. D., et al. European society for hypertermic oncology. Randomised trial for hyperthermia as adjuvant to radiotherapy for recurrent or metastatic malignant melanoma. Lancet, 1995: 345: 540–543.
9. Eton, O., Legha, S. S., et al. Sequential biochemotherapy versus chemotherapy for metastatic melanoma: results from phase III randomized trial. J. Clin. Oncol., 2002: 20: 2045–2052.
10. Keiholz, U., Conradt, C., Legha, S. S., et al. Results of interleukin-2-based treatment in advanced melanoma: a case record-based analysis of 631 patients. J. Clin. Oncol., 1998: 16: 2921–2929.
11. Koops, H. S. Is isolated limb perfusion of metastatic malignant melanoma of the extremity worthwhile. Eur. J. Cancer, 1996; 32: 1633–1640.
12. Krementz, E. T., Carter, R. D., Sutherland, C. M., et al. Regional chemotherapy for melanoma: a 36 year experience. Ann. Surg., 1994; 220: 520–535.
13. Krementz, E. T., Sutherland, C. M., Muchmore, J. H. Isolated hyperthermia chemotherapy perfusion for limb melanoma. Surg. Clin. North Am., 1996; 76: 1313–1330.
14. Klasse, J. M., Kroon, B. B. R., van Geel, A. N., et al. Limb recurrence-free interval and survival in patients with recurrent melanoma of the extremities treated with normothermic isolated perfusion. J. Am. Coll. Surg., 1994; 178: 564–572.
15. Grunhagen, D. J., Brunstein, F., Graveland, W. J., et al. One hundred consecutive isolated limb perfusions with TNF-alpha and melphalan in melanoma patients with multiple in-transit metastases. Ann. Surg., 2004; 240: 939–948.
16. Creech, D. G., Krementz, E. T., Ryan, R. F., Winblad, J. N. Chemotherapy of cancer: regionalperfusion utilising an extracorporeal circuit. Ann. Surg., 1958; 148: 616–632.
17. Fraker, D., Alexander, H., Ross, M., et al. A phase III trial of isolated limb perfusion for extremity melanoma comparing melphalan alone versus melphalan plus tumor necrosis factor (TNF) plus interferon gamma [abstract]. Ann. Surg. Oncol., 2002; 9: S8.
18. Rossi, C. R., Foletto, M., Pilati, P., Mocellin, S., Lise, M. Isolated limb perfusion in locally advanced cutaneous melanoma. Semin. Oncol., 2002; 29: 400–409.
19. Benckhuijsen, C., Kroon, B. B., van Geel, A. N., Wieberdink, J. Regional perfusion treatment with melphalan for melanoma in a limb: an evaluation of drug kinetics. Eur. J. Surg. Oncol., 1988; 14: 157–163.
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