Bleeding during anticoagulant and antiaggregation therapy as a cause of acute abdomen
Authors:
M. Hekerová
Authors place of work:
Chirurgické oddělení, Nemocnice s poliklinikou Havířov, p. o.
primář: MUDr. B. Firla
Published in the journal:
Rozhl. Chir., 2017, roč. 96, č. 10, s. 438-441.
Category:
Case Report
Summary
Pradaxa (dabigatrani etexilati mesilas) belongs to a new group of anticoagulants, its pharmacological properties enabling uniform dosage without a need for monitoring the anticoagulant effect. It is an oral direct thrombin inhibitor. Pradaxa is the first NOAC (new oral anticoagulant) with a specific reversal agent called Praxbind (idarucizumab).
Dabigatran is indicated for the prophylaxis of venous thromboembolism in elective hip or knee replacements, for the prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation, as well as for the treatment of deep vein thrombosis and pulmonary embolism and also their recurrence in adult patients.
Key words:
dabigatrani etexilati − anticoagulant therapy – thromboembolism − idarucizumab
Zdroje
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4. Reilly PA, Ivan Ryn J, Grottke O, et al. Idarucizumab, a specific reversal agent for dabigatran: mode of action, pharmacokinetics and pharmacodynamics, and safety and efficacy in phase 1 subjects. Am J Med. 2016;129(11S):S64−72.
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6. Pradaxa. Souhrn údajů o přípravku. www. sukl.cz.
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8. Schiele F, van Ryn J, Canada K, et al. A specific antidote for dabigatran: functional and structural characterization. Blood 2013;121:3554–62.
9. Praxbind. Souhrn údajů o přípravku. www. sukl.cz.
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Štítky
Surgery Orthopaedics Trauma surgeryČlánok vyšiel v časopise
Perspectives in Surgery
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