The role of perioperative chemoimmunotherapy in the treatment of potentially resectable MSI-H gastric adenocarcinoma – a case report
Authors:
T. Sokop 1
; M. Kysela 1
; F. Sládek 2; R. Lordick Obermannová 1
Authors place of work:
Klinika komplexní onkologické, péče LF MU a MOÚ, Brno
1; Klinika operační onkologie, LF MU a MOÚ, Brno
2
Published in the journal:
Rozhl. Chir., 2024, roč. 103, č. 11, s. 458-461.
Category:
Case Report
doi:
https://doi.org/10.48095/ccrvch2024458
Summary
Introduction: Gastric and gastroesophageal junction adenocarcinoma is a disease with high mortality. Approximately 10% of these tumors are characterized by microsatellite instability with a presumed good response to immunotherapy. So far, treatment with checkpoint inhibitors is part of palliative regimens, in the Czech Republic this treatment is reimbursed in patients with MSI-H gastroesophageal adenocarcinoma exhibiting a combined positive score ≥ 5. Promising results of immunotherapy used in the early stages of MSI-H gastroesophageal adenocarcinoma were published recently.
Case report: A 59-year-old woman with locally advanced poorly cohesive MSI-H adenocarcinoma of the small curvature of the stomach. Based on the indication of the multidisciplinary team, she started neoadjuvant treatment with chemoimmunotherapy. The outcome was significant partial regression of the primary tumor and infiltrated gastric lymph nodes. Subsequently, the patient underwent uncomplicated radical total gastrectomy with D2 lymphadenectomy. After a short postoperative recovery, she continues adjuvant treatment with immunotherapy, so far with good tolerance.
Conclusion: This case report supports the potential importance of immunotherapy in the treatment of resectable locally advanced MSI-H gastric cancer, which is currently being evaluated in clinical trials.
Keywords:
immunotherapy – immune checkpoint inhibitors – gastroesophageal adenocarcinoma – microsatellite instability – perioperative treatment
Zdroje
Štítky
Surgery Orthopaedics Trauma surgeryČlánok vyšiel v časopise
Perspectives in Surgery
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