Colon cancer – neoadjuvant treatment of non-metastatic disease

Czech version

Authors: J. Tomášek ¹ ; L. Fiala ²
Authors‘ workplace: Klinika komplexní, onkologické péče, LF MU a MOÚ, Brno ¹; Klinika operační onkologie, LF MU a MOÚ, Brno ²
Published in: Rozhl. Chir., 2025, roč. 104, č. 3, s. 97-100.
Category: Review
doi: https://doi.org/10.48095/ccrvch202597

Overview

Neoadjuvant treatment for colon cancer, unlike rectal cancer, is rarely used. Its position in the treatment algorithm is not precisely defined. This treatment should be considered for locally significantly advanced tumors (cT4) with extensive nodal involvement. The neoadjuvant treatment plan should be determined in a multidisciplinary team setting. We describe the main clinical trials focused on neoadjuvant chemotherapy in colon cancer. A special subgroup is dMMR/MSI-high tumors, patients with such cancers are candidates for immunotherapy treatment. Immunotherapy can induce complete remission, but can also be accompanied by long-term or permanent toxicity of the treatment. Neoadjuvant immunotherapy of non-metastatic colon cancer is the subject of a number of clinical trials. Currently, no immunotherapy is registered in the EU for the neoadjuvant treatment of early colon cancer.

Keywords:

neoadjuvant therapy – early stage – colon cancer

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MUDr. Jiří Tomášek, Ph.D.

Klinika komplexní onkologické péče

LF MU a MOÚ

Žlutý kopec 7

656 53 Brno

jiri.tomasek@mou.cz