Carcinoma of vagina

Česká verzia

Authors: prim. MUDr. Josef Chovanec, Ph.D.
Authors place of work: Gynekologicko-porodnická klinika LF MU a FN Brno
Published in the journal: Prakt Gyn 2006; 10(2): 74-77

Summary

Malignant diseases of the vagina are either primary vaginal cancers or metastatic from adjacent or distant organs. Primary vaginal carcinoma is rare, constituting only 1–2% of all malignant gynecological tumors. It can be effectively treated, and when found in early stages, is often curable. Squamous cell vaginal cancer (approximately 85% of cases) initially spreads superficially within the vaginal wall and later invades the paravaginal tissues and the parametria. Adenocarcinoma (approximately 5–15% of cases) has a peak incidence between 17 and 21 years of age. Prognosis depends primarily on the stage of disease, but survival is reduced in patients who are greater than 60 years of age. Therapeutic alternatives depend on stage; surgery or radiation therapy is highly effective in early stages, while radiation therapy is the primary treatment of more advanced stages. Chemotherapy has not been shown to be curative for advanced vaginal cancer.

Key words:
carcinoma of vagina – etiology – therapy

Zdroje

1. Lee YC, Holcomb K, Buhl A. A rapid progression of primary vaginal squamous cell carcinoma in a zouny HIV-infected woman. Gynecol Oncol 2000; 78: 380-382.

2. Herman JM. Is hysterectomy a risk factor for vaginal cancer? JAMA 1986; 256: 601-603.

3. Aho M, Vesterinen E, Mezer B. Natural history of vaginal intraepithelial neoplasia. Cancer 1991; 68: 195-197.

4. Gallup DG, Talledo OE, Shah KJ et al. Invasive squamous cell carcinoma of the vagina: a 14-year study. Obstet Gynecol 1987; 69 (5): 782-785.

5. Herbst AL, Robboy SJ, Scully RE et al. Clear-cell adenocarcinoma of the vagina and cervix in girls: analysis of 170 registry cases. Am J Obstet Gynecol 1974; 119 (5): 713-724.

6. Herman JM. Is hysterectomy a risk factor for vaginal cancer? JAMA 1986; 256: 601-603.

7. Pukala E, Weiderpass E. Time trends in socio-economic differences in incidence rates of cancor of the Breast and female genital organs. Int Journ Cancer 1999; 81: 56-61.

8. Carthew P. Tamoxifen induces endometrial and vaginal cancer in rats in the absence of endometrial hyperplasia. Carcinogenesis 2000; 21: 793-797.

9. Eddy GL, Marks RD jr, Miller MC et al. Primary invasive vaginal carcinoma. Am J Obstet Gynecol 1991; 165 (2): 292-298.

10. Dixit S, Singhal S, Baboo HA. Squamous cell carcinoma of the vagina: a review of 70 cases. Gynecol Oncol 1993; 48 (1): 80-87.

11. Vagina. In: American Joint Committee on Cancer. AJCC Cancer Staging Manual. 6th ed. New York: Springer 2002; 251-257.

12. Stock RG, Chen AS, Seski J. A 30-year experience in the management of primary carcinoma of the vagina: analysis of prognostic factors and treatment modalities. Gynecol Oncol 1995; 56 (1): 45-52.

13. Gonzalez S, Flores MG, Chavez BJ et al. Topical 5-fluorouracil for treatment of vaginal intraepithelial neoplazma. Ginecol Obstet Mex 2002; 70, 244-247.

14. Abeloff MD, Armitage JO, Richter AS et al. Clinical Oncology. 3rd ed. Philadelphia: Elsevier 2004; 2256-2263.