Hereditary angioedema in gravidity

Česká verzia

Authors: MUDr. Barbora Kuřecová ¹; MUDr. Petr Janků ¹; prof. MUDr. Jiří Litzman, CSc. ²
Authors place of work: Gynekologicko-porodnická klinika LF MU a FN Brno ¹; Ústav klinické imunologie a alergologie LF MU a FN u sv. Anny v Brně ²
Published in the journal: Prakt Gyn 2006; 10(2): 57-59

Summary

The C1 inhibitor (C1 INH) deficiency is a rare, autosomal dominant imunologic disorder, which causes clinical disease named hereditary angioedema. This diease is characterised by a quick developement of painless and nonpruritic oedemas of subcutaneous and submucosal tissues. If gut mucosa is involved, the clinics resemble an acute abdomen. The laryngeal oedema may be lethal. Oedemas are caused by lack of C1 INH, complement cascade is not regulated properly and different vasoactive peptides are released. C1 inhibitor function is reduced due to impaired transcription (type I) or production of non functional protein (type II). Attacks are precipitated by physical insults, stress or infection. Most of the drugs used as prophylactic treatment are contraindicated in pregnancy. Moreover, labor is a kind of physical and psychological stress. Therefore pregnant women with hereditary angioedema should be carefully observed and treated in cooperation with immunologist.

Key words:
edema – complement – vasoactive substances – C1 inhibitor – hereditary angioedema – gravidity

Zdroje

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