The role of homocysteine and related thiols in etiopathogenesis of human reproduction disorders

Česká verzia

Authors: M. Králíková ¹; I. Crha ² ; J. Melounová ¹
Authors place of work: Biochemický ústav, LF MU, Brno ¹; Gynekologicko-porodnická klinika, LF MU a FN Brno ²
Published in the journal: Prakt Gyn 2011; 15(2): 78-82
Category: Review Article

Summary

Metabolism of homocysteine and related thiols plays an important role in many physiological processes of the human reproductive system. Its disturbances influence methylation reactions and are strongly associated with an increased risk of oxidative stress. An imbalance between overproduction of free radicals and efficacy of antioxidant systems in germ cells is considered to be the fundamental factor in cell membrane and DNA injuries. Hyperhomocysteinemia inhibits the methylation reactions that play an important role in DNA repairs and genom stabilisation. The aim of the study was to provide an overview of current knowledge on the association between metabolism of homocysteine and related thiols and human reproduction.

Key words:
homocysteine – glutathione – thiols – oxidative stress – infertility

Zdroje

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