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Ulipristal acetate: new antiretroviral drug in treatment of uterine fibroids


Authors: Kristýna Kubínová
Authors place of work: Gynekologicko-porodnická klinika 1. LF UK a VFN v Praze, přednosta prof. MUDr. A. Martan, DrSc.
Published in the journal: Prakt Gyn 2012; 16(2-4): 77-79
Category: Gynecology and Obstetrics: Review Article

Summary

In patients with symptomatic uterine fibroids the dominant therapeutic modality is still surgery (hysterectomy, myomectomy) or radiological treatment (uterine artery embolization, focused ultrasound). Causal pharmacological treatment has until recently been limited to the use of Gonadoliberine analogues (GnRHa). In research for the new pharmacological options it was observed that progesterone and its receptors induce proliferative activity in uterine fibroid cells and therefore treatment with antiprogesterones may be used in patients with uterine fibroids. These substances include for example: mifeproston, its effect on fibroid volume reduction has been demonstrated in several clinical trials and telapriston and asoprisnil. The development of telapriston and asoprisnil was stopped in phase III clinical trials due to hepatotoxicity or negative effect on the endometrium. Currently, new per-oral drug containing ulipristal acetate has been introduced to the Czech market. Ulipristal acetate belongs to the so called Selective Progesterone Receptor Modulator (SPRM) family. It has recently completed Phase III clinical trials and has acquired a license for clinical use in Europe. Although further studies are needed to assess the long-term results and safety of prolonged use ulipristal acetate, undoubtedly this drug represents a new and promising treatment option for patients with uterine fibroids.

Key words:
uterine fibroid – Selective Progesterone Receptor Modulator – ulipristal acetate


Zdroje

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Štítky
Paediatric gynaecology Gynaecology and obstetrics Reproduction medicine
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