New laboratory diagnostic techniques and prediction of preeclampsia

Summary

Detection of preeclampsia is still challenging for gynecologists and obstetricians. Clinicians consider only non-specific complaints and clinical signs in diagnosis process. An important aid offers ultrasound examination of fetus and uterine arteries. Up to now we can evaluate pathological findings from laboratory tests such as liver function tests, renal examination parameters, uric acid, blood coagulation or platelet count only in developed preeclampsia or in onset of eclampsia. Logically, researchers were challenged to find objective laboratory parameters with higher sensitivity and specificity useful in diagnosis of preeclampsia and ideally also in its prediction.

Key words:
angiogenic dysbalance – eclampsia – preeclampsia – placentar growth factor – plGF – fms-like tyrosine kinase-1 – sFlt-1