Non-hormonal therapy of climacteric syndrome

Česká verzia

Authors: Tomáš Fait
Authors place of work: Gynekologicko-porodnická klinika 1. LF UK a VFN v Praze
Published in the journal: Prakt Gyn 2015; 19(2): 123-126
Category: Climacteric medicine: Review article

Summary

Besides hormone replacement therapy we can use nonhormonal therapy for acute climacteric syndrome. The nonhormonal farmacotherapy is based on fytoestrogens. The influence of fytoestrogens on long term changes from estrogen deficinency has not been confirmed. On opossite side the effect on acute climacteric syndrome is clear. Short overview of possible nonhormonal solution is given with focus on fytoestrogenes.

Key words:
estrogen deficiency – climacteric syndrome – fytoestrogenes – nonhormonal therapy

Zdroje

1. Taku K, Melby MK, Kronenberg F et al. Extracted or synthesized soybean isoflavones reduce menopausal hot flash frequency and severity: systematic review and meta-analysis of randomized controlled trials. Menopause 2012; 19(7): 776–790.

2. Nappi RE, Malavasi B, Brundu B. Efficacy of Cimicifuga racemosa on climacteric complaints: a randomized study versus low-dose transdermal estradiol. Gynecol Endocrinol 2005; 20(1): 30–35.

3. Bai W, Henneicke-von Zepelin HH, Wang S et al. Efficacy and tolerability of a medicinal product containing an isopropanolic black cohosh extract in Chinese women with menopausal symptoms: a randomized, double blind, parallel-controlled study versus tibolone. Maturitas 2007; 58(1): 31–41.

4. Seidlova-Wuttke D, Hesse O, Jarry H et al. Evidence for selective estrogen receptor modulator activity in a black cohosh (Cimicifuga racemosa) extract: comparison with estradiol-17beta. Eur J Endocrinol 2003; 149(4): 351–362.

5. Qiu SX, Dan C, Ding LS et al. A triterpene glycoside from black cohosh that inhibits osteoclastogenesis by modulating RANKL and TNFalpha signaling pathways. Chem Biol 2007; 14(7): 860–869.

6. Powell SL, Gödecke T, Nikolic D et al. In Vitro Serotonergic Activity of Black Cohosh and Identification of Nω-Methylserotonin as a Potential Active Constituent. J Agric Food Chem 2008; 56(24): 11718–11726.

7. Kennelly EJ, Baggett S, Nuntanakorn P et al. Analysis of thirteen populations of black cohosh for formononetin. Phytomedicine 2002; 9(5): 461–467.

8. Burdette JE, Jianghua Liu J, Chen S et al. Black Cohosh Acts as a Mixed Competitive Ligand and Partial Agonist of the Serotonin Receptor. J Agric Food Chem 2003, 51 (19): 5661–5670.

9. Liggins J, Bluck LJ, Runswick S et al. Daidzein and genistein content of fruits and nuts. J Nutr Biochem 2000; 11(6):326–331.

10. Albert A, Altabre C, Baró F et al. Efficacy and safety of a phytoestrogen preparation derived from Glycine max (L.) Merr in climacteric symptomatology: a multicentric, open, prospective and non-randomized trial. Phytomedicine 2002; 9(2): 85–92.

11. Atkinson C, Newton KM, Bowless EJ et al. Demographic, anthropometric, and lifestyle factors and dietary intakes in relation to daidzein-metabolizing phenotypes among premenopausal women in USA. Am J Clin Nutr 2008; 87(3): 679–687.

12. Fait T, Donát J, Jeníček J et al. Doporučení pro hormonální substituční terapii v postmenopauze. Čes Gynek 2010; 75(2): 109–110.

13. Nikader E, Rutanen EM, Nieminen P et al. Lack of effect of isoflavonoids on the vagina and endometrium in postmenopausal women. Fertil Steril 2005; 83(1): 137–142.

14. Raimondi S, Roncaglia L, De Lucia M et al. Bioconversion of soy isoflavones daidzin and daidzein by Bifidobacterium strains. Appl Microbiol Biotechnol 2009; 81(5): 943–950.

15. Reeds SD, Newton KM, LaCroix AZ et al. Vaginal, endometrial and reproductive hormone findings: HALT study. Menopause 2008; 15(1): 51–58.

16. Unfer V, Casini ML, Costabile Let al. Endometrial effects of long-term treatment with phytoestrogens: a randomized, double blind, placebo-controlled study. Fertil Steril 2004; 82(1): 145–148.

17. Yuan JP, Wang JH, Liu X. Metabolism of dietary soy isoflavones to equol by human intestinal microflora. Mol Nutr Food Res 2007; 51(7): 765–781.