PATHOLOGY OF THE PROSTATE AND ANDROGEN AND ESTROGEN LEVELS
Authors:
prof. MUDr. Rajko Doleček; DrSc. 1; MUDr. Jan Krhut 2; MUDr. David Němec 2
Authors place of work:
Interní klinika FNsP Ostrava
1; urologické oddělení FNsP Ostrava
2
Published in the journal:
Urol List 2006; 4(4): 38-44
Summary
127 men aged 40 - 49, 50 - 59, 60 - 60, and over 70 were examined, of whom 64 were without prostatic pathology (WPP), 38 with benign prostatic hyperplasia (BPH), and 25 with prostate cancer (CaP). All of them were screened for blood levels of testosterone, dihydrotestosterone (DHT), free testosterone (F-TESTO), DHEA-S, 17ß-estradiol, cortisol before/after ACTH (07-14-21:00 hrs), as well as ACTH, prolactin, FSH, LH, and SHBG. The BPH and CaP group aged 60 - 69 had significantly higher levels of both testosterone and DHT as compared with the WPP group. The BPH men (? 70) had higher F-TESTO levels (but not significantly) than men in the WPP group. After ACTH, an increase in 17ß-estradiol was recorded in the BHP, and partly also in the CaP group. No such increase was recorded for the WPP group. These differences may play a role in the pathogenesis of both BPH and CaP. Response of catabolic cortisol to ACTH increases in elderly men as they advance in age, while their anabolic hormones (testosterone, DHT, F-TESTO, DHEA-S) decline.
KEY WORDS:
without prostatic pathology (WPP), benign prostatic hyperplasia (BPH), cancer of prostate (CaP), testosterone, dihydrotestosterone (DHT), free testosterone, DHEA-S, 17ß-estradiol, cortisol, ACTH, prolactin, FSH, LH, SHBG
Zdroje
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Štítky
Paediatric urologist UrologyČlánok vyšiel v časopise
Urological Journal
2006 Číslo 4
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