WHAT'S NEW IN PROSTATE CANCER PATHOLOGY ASSESMENT IN 2006
Authors:
Jonathan I. Epstein M. D.
Authors place of work:
Oncology, The Johns Hopkins Hospital
; Baltimore, MD
; Departments of Pathology, Urology and
Published in the journal:
Urol List 2006; 4(4): 5-9
Summary
This review summarizes developments over the last year in the pathology of prostate cancer and its precursors. Issues relating to the pathology are critical in the diagnosis, management, and prognostication of prostate cancer. New data has emerged regarding the pathology of prostate cancer and its precursors. The diagnosis of prostate cancer on needle biopsy has been refined as a result of the recent discovery of AMACR, which preferentially labels adenocarcinoma of the prostate. Modifications and additions to the Gleason grading system were published based on a consensus conference of urological pathologists. Various models have been proposed using Gleason score, clinical findings, as well as measurements of tumor volume on needle biopsy to enhance the prediction in men undergoing radical prostatectomy and to predict “insignificant”. Several studies have confirmed that certain findings in radical prostatectomy are adverse, yet conflicting studies were published as to the independent prognosis of tumor volume. The risk of cancer following a diagnosis of high grade prostatic intraepithelial neoplasia (HGPIN) on needle biopsy has decreased to the point where this author does not recommend a routine repeat needle biopsy within the first year following the diagnosis of HGPIN.
KEY WORDS:
Gleason score, prostatic intraepithelial neoplasia, radical prostatectomy, margins, seminal vesicle invasion, AMACR
Zdroje
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Štítky
Paediatric urologist UrologyČlánok vyšiel v časopise
Urological Journal
2006 Číslo 4
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