Cancer treatment induced bone loss (CTIBL): burning issue in prostate cancer patients – our experience
Authors:
Prof. MUDr. Dalibor Pacík, CSc. 1; as. MUDr. Vítězslav Vít 1; prim. MUDr. Jana Katolická, Ph.D. 2; RNDr. Jiří Jarkovský, Ph.D. 3
Authors place of work:
Urologická klinika LF MU, FN Brno
1; Onkologicko-chirurgické oddělení, FN u sv. Anny Brno
2; Institut biostatistiky a analýz, MU Brno
3
Published in the journal:
Urol List 2011; 9(1): 60-64
Summary
Androgen deprivation therapy (ADT) is well established in locally advanced or metastatic prostate cancer patients management. Its contribution to the prognosis of these patients is undisputable; CTIBL as its consequence is discussed in a much lesser extent. Cancer treatment induced bone loss leads ultimately to increased morbidity and mortality as well as to increased societal costs. We investigated the presence of osteoporosis and osteopenia based on bone mineral density measurement at DXA in a group of
104 patients at our clinic. The following article presents our data and considers new treatment option for patients suffering from CTIBL presented by a new monoclonal antibody denosumab.
Key words:
androgen deprivation therapy (ADT), BMD, RANKL, denosumab, prostate cancer, pathological fractures
Zdroje
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Štítky
Paediatric urologist UrologyČlánok vyšiel v časopise
Urological Journal
2011 Číslo 1
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