Treatment of metastatic bladder cancer, systemic chemotherapy, symptomatic treatment

Česká verzia

Authors: J. Katolická
Authors place of work: Onkologicko-chirurgické oddělení FN u svaté Anny v Brně
Published in the journal: Urol List 2012; 10(2): 54-56

Summary

Chemotherapy is the standard approach for inoperable locally advanced or metastatic cancer treatment. The recommended chemotherapeutical regime for the first line treatment includes gemcitabin/cisplatin, which has replaced M-VAC. Based on III phase study results we can recommend vinflunin for the second line treatment of urothelial cancer after cisplatin (as the first line regime) intolerance/failure.

Key words:
chemotherapy, cisplatin, gemcitabin, vinflunin

Zdroje

1. Sternberg CN, Yagoda A, Scher HI et al. Methotrexate, vinblastine, doxorubicin and cisplatin for advanced transitional cell carcinoma of the urothelium. Efficacy and patterns of response and relapse. Cancer 1989; 64(12): 2448–2458.

2. Loehrer PJ Sr., Einhorn LH, Elson PJ et al. A randomized comparison of cisplatin alone or in combination with methotrexate, vinblastine and doxorubicin in patients with metastatic urothelial carcinoma: a cooperative group study. J Clin Oncol 1992; 10(7): 1066–1073.

3. Logothetis CJ, Dexeus FH, Finn L et al. A prospective randomized trial comparing MVAC and CISCA chemotherapy for patients with metastatic urotelial tumors. J Clin Oncol 1990; 8(6): 1050–1055.

4. Sternberg CN, de Mulder PH, Schornagel JH et al. Randomized phase III trial of high-dose-intensity methotrexate, vinblastine, doxorubicin and cisplatin (MVAC) chemotherapy and recombinant human granulocyte colony-stimulating factor versus classic MVAC in advanced urothelial tract tumors: European Organization for Research and Treatment of Cancer protocol no. 30924. J Clin Oncol 2001; 19(10): 2638–2646.

5. von der Maase H, Hansen SW, Roberts JT et al. Gemcitabine and cisplatine versus methotrexate, vinblastine, doxorubicin and cisplatin in advanced or metastatic bladder cancer: results of a large, randomized, multinational, multicenter, phase III study. J Clin Oncol 2000; 18(17): 3068–3077.

6. Bellmunt J, von der Maase H, Mead GM et al. Randomized phase III study comparing paclitaxel//cisplatine/gemcitabine (PCG) and gemcitabine//cisplatin (GC) in patients with locally advanced (LA) or metastatic (M) urothelial cancer without prior systemic therapy. American Society of Clinical Oncology Annual Meeting 2007; Chicago, IL.

7. Bamias A, Aravantinos G, Deliveliotis C et al. Docetaxel and cisplatinwith granulocyte colony-stimulatingfactor (G-CSF) versus MVAC with G-CSF in advanced urothelial carcinoma: a multicenter, randomized phase III study from Helenic Cooperative Oncology Group. J Clin Oncol 2004; 22(2): 220–228.

8. Dreicer R, Manola J, Roth BJ et al. Phase III trial methotrexate, vinblastine, doxorubicin and cisplatin versus carboplatin and paclitaxel in patients with advanced carcinoma of urotelium. Cancer 2004; 100(8): 1639–1645.

9. Hahn NM, Stadler WM, Zon R et al. Mature results from Hoosier Oncology Group GU 04-75 phase II trial of cisplatin (C), gemcitabine (G) and bevacizumab (B) as first-line chemotherapy for metastatic urothelial carcinoma (UC). American Socienty of Clinical Oncology Annual Meeting: 2010. Chicago, IL.

10. Hussain RS, Vaishampayan U, Du W et al. Combination paclitaxel, carboplatin, and gemcitabine is an active treatment for advanced urothelial cancer. J Clin Oncol 2001; 19(9): 2527–2533.

11. Bellmunt J, Theodore C, Demkov Z et al. Phase III trial of vinflunine plus best supportive care compared with best supportive care alone after a platinum-containing regimen in patients with advanced transitional cell carcinoma of the urothelial tract. J Clin Oncol 2009; 27(27): 4454–4461.

12. Albers P, Park SI, Niegisch G et al. Randomized phase III trial of 2¨^nd line gemcitabine and paclitaxel chemotherapy in patients with advanced bladder cancer: short-term versus prolonged treatment (German Association of Urological Oncology (AUO) trial AB 20/99) Ann Oncol 2011; 22(2): 288–294