Tau protein a anti-tau protilátky u pacientů s roztroušenou sklerózou

Cíl:
Poškození neuronů u roztroušené sklerózy (RS) může být doprovázeno uvolňováním cytoskeletálního tau proteinu, který interaguje s narušenými složkami imunitního systému za vzniku autoprotilátek. Koncentrace tau proteinu mohou být ovlivněny přítomností protilátek proti tau proteinu v séru a mozkomíšním moku (MMM).

Metody:
Tau protein i protilátky proti tau proteinu jsme stanovovali pomocí metod ELISA u 31 pacientů (14 pacientů s RS a 17 kontrolních neurologických pacientů). Vypočítali jsme tři poměry tau proteinu vztahující se ke koncentraci a) anti-tau protilátek v MMM, b) anti-tau protilátek v séru a c) intratékálně produkovaných anti-tau protilátek.

Výsledky:
Neprokázali jsme statisticky významné korelace mezi koncentracemi tau proteinu a protilátek proti tau proteinu v séru, v MMM ani anti-tau protilátek intratékálně produkovaných. Koncentrace tau proteinu v MMM ani žádný z vypočtených poměrů se nelišily mezi skupinou pacientů s RS a kontrolních pacientů.

Závěr:
Uvolňování tau proteinu do MMM a protilátková odpověď proti tau proteinu u RS jsou zřejmě na sobě nezávislé procesy, podobně jako u jiných neurologických pacientů.

Klíčová slova:
tau protein – autoprotilátky – mozkomíšní mok – roztroušená skleróz

Autoři: L. Fialová ¹; A. Bartošihash2 ^{2,3 1,4}
Působiště autorů: Charles University in Prague, First Faculty of Medicine, Institute of Medical Biochemistry, Prague ¹; Charles University in Prague, Third Faculty of Medicine, University Hospital Královské Vinohrady, Department of Neurology, Prague ²; Prague Psychiatric Center ³; Institute of Clinical Biochemistry and Laboratory Diagnostics, General University Hospital, Prague ⁴
Vyšlo v časopise: Cesk Slov Neurol N 2012; 75/108(3): 310-313
Kategorie: Původní práce

Souhrn

Závěr:
Uvolňování tau proteinu do MMM a protilátková odpověď proti tau proteinu u RS jsou zřejmě na sobě nezávislé procesy, podobně jako u jiných neurologických pacientů.

Klíčová slova:
tau protein – autoprotilátky – mozkomíšní mok – roztroušená skleróz

Zdroje

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