Giant-cell lesions of bone and their differential diagnosis

Česká verzia

Authors: C. Povýšil
Authors place of work: Ústav patologie 1. LF UK a VFN v Praze
Published in the journal: Čes.-slov. Patol., 48, 2012, No. 3, p. 141-145
Category: Přehledový článek

Summary

Giant-cell lesions of bone-neoplastic and reactive growths form a group of clinicopathological entities that differ in their behaviour and may present substantial problems in differential diagnosis. The presence of multinucleated giant cells of the osteoclast type, reactive osteoplasia and the formation of secondary aneurysmal cysts in many unrelated lesions of bone further complicates their classification. Clinicopathologic correlation of all findings, including the radiologic features and laboratory tests, is of paramount importance in reaching a correct diagnosis in this group of histologically overlapping entities. Malignant features can be identified in the primary and secondary conventional malignant giant cell tumours and in some types of osteosarcoma with a giant cell component.

Keywords:
giant-cell lesions of bone – giant-cell tumor – osteoclast – osteosarcoma

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