Molekulární epidemiologie viru Varicella zoster

Varicela zoster virus (VZV) se vyznačuje vysoce konzervativním genomem, obsahujícím přibližně 125 000 nukleotidových párů bází.

Článek přehledně shrnuje vývoj molekulárně genetických přístupů zkoumání VZV v průběhu posledních deseti let. Autoři se zabývají výstupy těchto metod, jako jsou fylogenetické vztahy mezi jednotlivými kmeny VZV, jejich virulencí, geografickou distribucí, možnými rekombinacemi.

Klíčová slova :
varicela zoster virus – DNA genom – genotypová analýza – single nuclotide polymorphism (SNP).

Autoři: V. Boštíková ¹ ; P. Boštík ⁴; R. Chlíbek ¹; D. S. Schmid ²; M. Salavec ³; J. Smetana ¹ ; M. Špliňo ¹
Působiště autorů: Dpt. of Epidemiology, Faculty of Military Health Science, University of Defence, Hradec Králové, Czech Republic ¹; Centers for Disease Control and Prevention, National Center for Immunizations and Respiratory Diseases, Atlanta, Georgia, USA ²; Dpt of Dermatology, Faculta Hospital, Hradec Králové, Czech Republic ³; Center of Advanced Studies, University of Defence, Czech Republic ⁴
Vyšlo v časopise: Epidemiol. Mikrobiol. Imunol. 59, 2010, č. 1, s. 21-24

Souhrn

Klíčová slova :
varicela zoster virus – DNA genom – genotypová analýza – single nuclotide polymorphism (SNP).

Zdroje

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