Význam analýzy nestinu u mnohočetného myelomu

Nestin, marker multipotentních prekurzorových buněk, představuje významnou dynamickou strukturu, jejíž polymerizace/depolymerizace ovlivňuje intracelulární signalizaci a podílí se na řadě klíčových buněčných procesů, jako je proliferace, migrace a přežívání buněk. Předpokládá se, že nestin hraje centrální roli v procesu karcinogeneze. Nestin je považován za možný diagnostický a prediktivní indikátor malignity solidních nádorů a potenciální marker nádorových kmenových buněk. Překvapivě byl identifikován i ve zralých CD138+38+ plazmatických buňkách (PC) mnohočetného myelomu (MM). Exprese markeru kmenových/progenitorových buněk v maligních PC, které jsou považovány za terminálně diferencované, indikuje, že nestin by mohl hrát významnou roli v patologii MM.

Klíčová slova:
nestin – plazmatické buňky – mnohočetný myelom – myelomové kmenové buňky – myelom-iniciující buňky – flowcytometrie

Tato práce byla podpořena výzkumnými projekty MŠMT ČR:
LC06027, MSM0021622434; granty IGA MZ ČR: NS10406, NS10408, NT11154 a granty GAČR GAP304/10/1395.

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Autoři: H. Šváchová ^1,2; L. Kovářová ^1,4; J. Štossová ¹; A. Potáčová ¹; L. Pour ^1,3; R. Hájek ^1,3,4
Působiště autorů: Babak Myeloma Group, Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic ¹; Department of Experimental Biology, Faculty of Science, Masaryk University ²; Department of Internal Medicine – Hematooncology, University Hospital Brno, Czech Republic ³; Laboratory of Experimental Hematology and Cell Immunotherapy, Department of Clinical Haematology, University Hospital Brno ⁴
Vyšlo v časopise: Klin Onkol 2011; 24(Supplementum 1): 53-57

Souhrn

Klíčová slova:
nestin – plazmatické buňky – mnohočetný myelom – myelomové kmenové buňky – myelom-iniciující buňky – flowcytometrie

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