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Genetic Variants in , , and Influence Male Recombination in Cattle


We use >250,000 cross-over events identified in >10,000 bovine sperm cells to perform an extensive characterization of meiotic recombination in male cattle. We map Quantitative Trait Loci (QTL) influencing genome-wide recombination rate, genome-wide hotspot usage, and locus-specific recombination rate. We fine-map three QTL and present strong evidence that genetic variants in REC8 and RNF212 influence genome-wide recombination rate, while genetic variants in PRDM9 influence genome-wide hotspot usage.


Vyšlo v časopise: Genetic Variants in , , and Influence Male Recombination in Cattle. PLoS Genet 8(7): e32767. doi:10.1371/journal.pgen.1002854
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1002854

Souhrn

We use >250,000 cross-over events identified in >10,000 bovine sperm cells to perform an extensive characterization of meiotic recombination in male cattle. We map Quantitative Trait Loci (QTL) influencing genome-wide recombination rate, genome-wide hotspot usage, and locus-specific recombination rate. We fine-map three QTL and present strong evidence that genetic variants in REC8 and RNF212 influence genome-wide recombination rate, while genetic variants in PRDM9 influence genome-wide hotspot usage.


Zdroje

1. RoederGS 1997 Meiotic chromosomes: it takes two to tango. Gene Dev 11 2600 2621

2. PageSLHawleyRS 2003 Chromosome choreography: the meiotic ballet. Science 301 785 791

3. CoopGPrzeworskiM 2007 An evolutionary view of human recombination. Nat Rev Genet 8 23 34

4. Martinez-PerezEColaiácovoMP 2009 Distribution of meiotic recombination events: talking to your neighbors. Curr Opin Genet Dev 19 105 120

5. HassoldTHuntP 2001 To err (meiotically) is human: the genesis of human aneuploidy. Nat Rev Genet 2 280 291

6. HandelMASchimentiJC 2010 Genetics of mammalian meiosis: regulation, dynamics and impact on fertility. Nat Rev Genet 11 124 136

7. BromanKWMurrayJCSheffieldVCWhiteRLWeberJL 1998 Comprehensive human genetic maps: individual and sex-specific variation in recombination. Am. J. Hum. Genet. 63 861 869

8. KongAGudbjartssonDFSainzJJonsdottirGMGudjonssonSA 2002 A high-resolution recombination map of the human genome. Nat Genet 31 241 247

9. KongABarnardJGudbjartssonDFThorleifssonGJonsdottirG 2004 Recombination rate and reproductive success in humans. Nat Genet 36 1203 1206

10. LenziMLSmithJSnowdenTKimMFishelR 2005 Extreme heterogeneity in the molecular events leading to the establishment of chiasmata during meiosis in human oocytes. Am J Hum Genet 76 112 127

11. StefanssonHHelgasonAThorleifssonGSteinthorsdottirVMassonG 2005 A common inversion under selection in Europeans. Nat Genet 37 129 137

12. KongAThorleifssonGStefanssonHMassonGHelgasonA 2008 Sequence variants in the RNF212 gene associate with genome-wide recombination rate. Science 319 1398 1401

13. ChowdhuryRBoisPRJFeingoldEShermanSLCheungVG 2009 Genetic analysis of variation in human meiotic recombination. PLoS Genet 5 e1000648 doi:10.1371/journal.pgen.1000648

14. MyersSBottoloLFreemanCMcVeanGDonnellyP 2005 A fine-scale map of recombination rates and hotspots across the human genome. Science 310 321 324

15. PaigenKPetkovP 2010 Mammalian recombination hot spots: properties, control and evolution. Nat Rev Genet 11 221 233

16. The 1,000 genomes project consortium 2010 A map of human genome variation from population-scale sequencing. Nature 467 1061 1073

17. CoopGWenXOberCPritchardJKPrzeworskiM 2008 High-resolution mapping of crossovers reveals extensive variation in fine-scale recombination patterns among humans. Science 319 1395 1398

18. JeffreysAJNeumannR 2009 The rise and fall of a human recombination hot spot. Nat Genet 41 625 629

19. ParvanovEDPetkovPMPaigenK 2010 Prdm9 controls activation of mammalian recombination hotspots. Science 327 835

20. BaudatFBuardJGreyCFledel-AlonAOberC 2010 PRDM9 is a major determinant of meiotic recombination hotspots in humans and mice. Science 327 836 840

21. MyersSBowdenRTumianABontropREFreemanC 2010 Drive against hotspot motifs in primates implicates the PRDM9 gene in meiotic recombination. Science 327 876 879

22. BergILNeumannRLamKWGSarbajnaSOdenthal-HesseL 2010 PRDM9 variation strongly influences recombination hot-spot activity and meiotic instability in humans. Nat Genet 42 859 863

23. PtakSEHindsDAKoehlerKNickelBPatilN 2005 Fine-scale recombination patterns differ between chimpanzees and humans. Nat Genet 37 429 434

24. WincklerWMyersSRRichterDJOnofrioRCMcDonaldGJ 2005 Comparison of fine-scale recombination rates in humans and chimpanzees. Science 308 107 111

25. MiholaOTrachtulecZVlcekCSchimentiJCForejtJ 2009 A mouse speciation gene encodes a meiotic histone H3 methyltransferase. Science 323 373 375

26. BromanKWWeberJL 2000 Characterization of human crossover interference. Am J Hum Genet 66 1911 1926

27. LianJYinYOliver-BonetMLiehrTKoE 2008 Variation in crossover interference levels on individual chromosomes from human males. Hum Mol Genet 17 2583 2594

28. MeuwissenTHHayesBJGoddardME 2001 Prediction of total genetic value using genome-wide dense marker maps. Genetics 157 1819 1829

29. Bovine Genome Sequencing and Analysis Consortium 2009 The Genome Sequence of Taurine Cattle: A Window to Ruminant Biology and Evolution. Science 324 522 528

30. IharaNTakasugaAMizoshitaKTakedaHSugimotoM 2004 A comprehensive genetic map of the cattle genome based on 3802 microsatellites. Genome Res 14 1987 1998

31. Ross-IbarraJ 2004 The evolution of recombination under domestication: a test of two hypotheses. Am Nat 163 105 112

32. CharlierCCoppietersWRollinFDesmechtDAgerholmJS 2008 Highly effective SNP-based association mapping and management of recessive defects in livestock. Nat Genet 40 449 454

33. MatukumalliLKLawleyCTSchnabelRDTaylorJFAllanMF 2009 Development and characterization of a high density SNP genotyping assay for cattle. PLoS ONE 4 e5350 doi:10.1371/journal.pone.0005350

34. DruetTGeorgesM 2010 A Hidden Markov Model combining linkage and linkage disequilibrium information for haplotype reconstruction and QTL fine mapping. Genetics 184 789 798

35. Fledel-AlonAWilsonDJBromanKWenXOberC 2009 Broad-scale recombination patterns underlying proper disjunction in humans. PLoS Genet 5 e1000658 doi:10.1371/journal.pgen.1000658

36. SturtESmithCA 1976 The relationship between chromatid interference and the mapping function. Cytogenet Cell Genet 17 212 220

37. PaigenKSzatkiewiczJPSawyerKLeahyNParvanovEDNgSHSGraberJHBromanKWPetkowPM 2008 The recombinational anatomy of a mouse chromosome. PLoS Genet 4 e1000119 doi:10.1371/journal.pgen.1000119

38. McPeekMSSpeedTP 1995 Modeling interference in genetic recombination. Genetics 139 1031 1044

39. BannisterLAReinholdtLGMunroeRJSchimentiJC 2004 Positional cloning and characterization of mouse mei8, a disrupted allelle of the meiotic cohesin Rec8. Genesis 40 184 194

40. XuHBeasleyMDWarrenWDDer Horst GTJvanMcKayMJ 2005 Absence of mouse REC8 cohesin promotes synapsis of sister chromatids in meiosis. Dev Cell 8 949 961

41. PontingCP 2011 What are the genomic drivers of the rapid evolution of PRDM9? Trends in Genetics 27 165 171

42. AxelssonEWebsterMTRatnakumarAConsortiumLPontingCPLindblad-TohK 2011 Death of PRDM9 coincides with stabilization of the recombination landscape in the dog genome. Genome Res Oct 17 [Epub ahead of print]

43. Munoz-FuentesVDi RienzoAVilaC 2011 PRDM9, a major determinant of meiotic recombination hotspots, is not functional in dogs and their wild relatives, wolves and coyotes. PLoS ONE 6 e25498 doi:10.1371/journal.pone.0025498

44. LiaoD 1999 Concerted evolution: molecular mechanism and biological implications. Am J Hum Genet 64 24 30

45. HousworthEAStahlFW 2009 Is there variation in crossover interference levels among chromosomes from human males? Genetics 183 403 405

46. HousworthEAStahlFW 2003 Crossover interference in humans. Am J Hum Genet 73 188 197

47. KabackDBBarberDMahonJLambJYouJ 1999 Chromosome-size dependent control of meiotic reciprocal recombination in S. cerevisiae: the role of crossover interference. Genetics 152 1475 1486

48. LynschMWalshB 1998 Genetics and Analysis of Quantitative Traits. AssociatesS (Sunderland).

49. JohnsonDLThompsonR 1995 Restricted Maximum Likelihood Estimation of Variance Components for Univariate Animal Models Using Sparse Matrix Techniques and Average Information. J Dairy Sci 78 449 456

50. ChurchillGADoergeRW 1996 Permutation tests for multiple loci affecting a quantitative character. Genetics 142 285 294

51. LanderEKruglyakL 1995 Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet 11 241 247

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Genetika Reprodukčná medicína

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PLOS Genetics


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