#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Hypothalamic Leptin Resistance: From BBB to BBSome


article has not abstract


Vyšlo v časopise: Hypothalamic Leptin Resistance: From BBB to BBSome. PLoS Genet 12(5): e32767. doi:10.1371/journal.pgen.1005980
Kategorie: Perspective
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1005980

Souhrn

article has not abstract


Zdroje

1. Coleman DL, Hummel KP (1969) Effects of parabiosis of normal with genetically diabetic mice. Am J Physiol 217: 1298–1304. 5346292

2. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L et al. (1994) Positional cloning of the mouse obese gene and its human homologue. Nature 372: 425–432. 7984236

3. Halaas JL, Gajiwala KS, Maffei M, Cohen SL, Chait BT et al. (1995) Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269: 543–546. 7624777

4. Myers MG, Cowley MA, Munzberg H (2008) Mechanisms of leptin action and leptin resistance. Annu Rev Physiol 70: 537–556. 17937601

5. Balland E, Cowley MA (2015) New insights in leptin resistance mechanisms in mice. Front Neuroendocrinol 39: 59–65. doi: 10.1016/j.yfrne.2015.09.004 26410445

6. Farooqi IS, O'Rahilly S (2005) Monogenic obesity in humans. Annu Rev Med 56: 443–458. 15660521

7. Lopez M, Tovar S, Vazquez MJ, Nogueiras R, Seoane LM et al. (2007) Perinatal overfeeding in rats results in increased levels of plasma leptin but unchanged cerebrospinal leptin in adulthood. Int J Obes (Lond) 31: 371–377.

8. Lopez M, Seoane LM, Tovar S, Garcia MC, Nogueiras R et al. (2005) A possible role of neuropeptide Y, agouti-related protein and leptin receptor isoforms in hypothalamic programming by perinatal feeding in the rat. Diabetologia 48: 140–148. 15616803

9. Contreras C, Gonzalez-Garcia I, Martinez-Sanchez N, Seoane-Collazo P, Jacas J et al. (2014) Central ceramide-induced hypothalamic lipotoxicity and ER stress regulate energy balance. Cell Rep 9: 366–377. doi: 10.1016/j.celrep.2014.08.057 25284795

10. Ottaway N, Mahbod P, Rivero B, Norman LA, Gertler A et al. (2015) Diet-induced obese mice retain endogenous leptin action. Cell Metab 21: 877–882. doi: 10.1016/j.cmet.2015.04.015 25980347

11. Guo DF, Cuim H, Zhang Q, Morgan DA, Thedens DRet al. (2016) The BBSome controls energy homeostasis by mediating the transport of the leptin receptor to the plasma membrane. PLoS Genet 12: e1005890. doi: 10.1371/journal.pgen.1005890 26926121

12. Guo DF, Rahmouni K (2011) Molecular basis of the obesity associated with Bardet-Biedl syndrome. Trends Endocrinol Metab 22: 286–293. doi: 10.1016/j.tem.2011.02.009 21514177

13. Novas R, Cardenas-Rodriguez M, Irigoin F, Badano JL (2015) Bardet-Biedl syndrome: Is it only cilia dysfunction? FEBS Lett 589: 3479–3491. doi: 10.1016/j.febslet.2015.07.031 26231314

14. Rahmouni K, Fath MA, Seo S, Thedens DR, Berry CJ et al. (2008) Leptin resistance contributes to obesity and hypertension in mouse models of Bardet-Biedl syndrome. J Clin Invest 118: 1458–1467. doi: 10.1172/JCI32357 18317593

15. Stratigopoulos G, Martin Carli JF, O'Day DR, Wang L, LeDuc CA et al. (2014) Hypomorphism for RPGRIP1L, a ciliary gene vicinal to the FTO locus, causes increased adiposity in mice. Cell Metab 19: 767–779. doi: 10.1016/j.cmet.2014.04.009 24807221

16. Starks RD, Beyer AM, Guo DF, Boland L, Zhang Q et al. (2015) Regulation of Insulin Receptor Trafficking by Bardet Biedl Syndrome Proteins. PLoS Genet 11: e1005311. doi: 10.1371/journal.pgen.1005311 26103456

17. Thaler JP, Yi CX, Schur EA, Guyenet SJ, Hwang BH et al. (2012) Obesity is associated with hypothalamic injury in rodents and humans. J Clin Invest 122: 153–162. doi: 10.1172/JCI59660 22201683

Štítky
Genetika Reprodukčná medicína

Článok vyšiel v časopise

PLOS Genetics


2016 Číslo 5
Najčítanejšie tento týždeň
Najčítanejšie v tomto čísle
Kurzy

Zvýšte si kvalifikáciu online z pohodlia domova

Aktuální možnosti diagnostiky a léčby litiáz
nový kurz
Autori: MUDr. Tomáš Ürge, PhD.

Všetky kurzy
Prihlásenie
Zabudnuté heslo

Zadajte e-mailovú adresu, s ktorou ste vytvárali účet. Budú Vám na ňu zasielané informácie k nastaveniu nového hesla.

Prihlásenie

Nemáte účet?  Registrujte sa

#ADS_BOTTOM_SCRIPTS#