The Effect of Chromosome 9p21 Variants on Cardiovascular Disease May Be Modified by Dietary Intake: Evidence from a Case/Control and a Prospective Study
Background:
One of the most robust genetic associations for cardiovascular disease (CVD) is the Chromosome 9p21 region. However, the interaction of this locus with environmental factors has not been extensively explored. We investigated the association of 9p21 with myocardial infarction (MI) in individuals of different ethnicities, and tested for an interaction with environmental factors.
Methods and Findings:
We genotyped four 9p21 SNPs in 8,114 individuals from the global INTERHEART study. All four variants were associated with MI, with odds ratios (ORs) of 1.18 to 1.20 (1.85×10−8≤p≤5.21×10−7). A significant interaction (p = 4.0×10−4) was observed between rs2383206 and a factor-analysis-derived “prudent” diet pattern score, for which a major component was raw vegetables. An effect of 9p21 on MI was observed in the group with a low prudent diet score (OR = 1.32, p = 6.82×10−7), but the effect was diminished in a step-wise fashion in the medium (OR = 1.17, p = 4.9×10−3) and high prudent diet scoring groups (OR = 1.02, p = 0.68) (p = 0.014 for difference). We also analyzed data from 19,129 individuals (including 1,014 incident cases of CVD) from the prospective FINRISK study, which used a closely related dietary variable. In this analysis, the 9p21 risk allele demonstrated a larger effect on CVD risk in the groups with diets low or average for fresh vegetables, fruits, and berries (hazard ratio [HR] = 1.22, p = 3.0×10−4, and HR = 1.35, p = 4.1×10−3, respectively) compared to the group with high consumption of these foods (HR = 0.96, p = 0.73) (p = 0.0011 for difference). The combination of the least prudent diet and two copies of the risk allele was associated with a 2-fold increase in risk for MI (OR = 1.98, p = 2.11×10−9) in the INTERHEART study and a 1.66-fold increase in risk for CVD in the FINRISK study (HR = 1.66, p = 0.0026).
Conclusions:
The risk of MI and CVD conferred by Chromosome 9p21 SNPs appears to be modified by a prudent diet high in raw vegetables and fruits.
: Please see later in the article for the Editors' Summary
Vyšlo v časopise:
The Effect of Chromosome 9p21 Variants on Cardiovascular Disease May Be Modified by Dietary Intake: Evidence from a Case/Control and a Prospective Study. PLoS Med 8(10): e32767. doi:10.1371/journal.pmed.1001106
Kategorie:
Research Article
prolekare.web.journal.doi_sk:
https://doi.org/10.1371/journal.pmed.1001106
Souhrn
Background:
One of the most robust genetic associations for cardiovascular disease (CVD) is the Chromosome 9p21 region. However, the interaction of this locus with environmental factors has not been extensively explored. We investigated the association of 9p21 with myocardial infarction (MI) in individuals of different ethnicities, and tested for an interaction with environmental factors.
Methods and Findings:
We genotyped four 9p21 SNPs in 8,114 individuals from the global INTERHEART study. All four variants were associated with MI, with odds ratios (ORs) of 1.18 to 1.20 (1.85×10−8≤p≤5.21×10−7). A significant interaction (p = 4.0×10−4) was observed between rs2383206 and a factor-analysis-derived “prudent” diet pattern score, for which a major component was raw vegetables. An effect of 9p21 on MI was observed in the group with a low prudent diet score (OR = 1.32, p = 6.82×10−7), but the effect was diminished in a step-wise fashion in the medium (OR = 1.17, p = 4.9×10−3) and high prudent diet scoring groups (OR = 1.02, p = 0.68) (p = 0.014 for difference). We also analyzed data from 19,129 individuals (including 1,014 incident cases of CVD) from the prospective FINRISK study, which used a closely related dietary variable. In this analysis, the 9p21 risk allele demonstrated a larger effect on CVD risk in the groups with diets low or average for fresh vegetables, fruits, and berries (hazard ratio [HR] = 1.22, p = 3.0×10−4, and HR = 1.35, p = 4.1×10−3, respectively) compared to the group with high consumption of these foods (HR = 0.96, p = 0.73) (p = 0.0011 for difference). The combination of the least prudent diet and two copies of the risk allele was associated with a 2-fold increase in risk for MI (OR = 1.98, p = 2.11×10−9) in the INTERHEART study and a 1.66-fold increase in risk for CVD in the FINRISK study (HR = 1.66, p = 0.0026).
Conclusions:
The risk of MI and CVD conferred by Chromosome 9p21 SNPs appears to be modified by a prudent diet high in raw vegetables and fruits.
: Please see later in the article for the Editors' Summary
Zdroje
1. MurrayCJLopezAD 1997 Alternative projections of mortality and disability by cause 1990–2020: Global Burden of Disease Study. Lancet 349 1498 1504
2. YusufSHawkenSOunpuuSDansTAvezumA 2004 Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study. Lancet 364 937 952
3. MarenbergMERischNBerkmanLFFloderusBde FaireU 1994 Genetic susceptibility to death from coronary heart disease in a study of twins. N Engl J Med 330 1041 1046
4. SheaSOttmanRGabrieliCSteinZNicholsA 1984 Family history as an independent risk factor for coronary artery disease. J Am Coll Cardiol 4 793 801
5. McPhersonRPertsemlidisAKavaslarNStewartARobertsR 2007 A common allele on chromosome 9 associated with coronary heart disease. Science 316 1488 1491
6. SamaniNJErdmannJHallASHengstenbergCManginoM 2007 Genomewide association analysis of coronary artery disease. N Engl J Med 357 443 453
7. HelgadottirAThorleifssonGManolescuAGretarsdottirSBlondalT 2007 A common variant on chromosome 9p21 affects the risk of myocardial infarction. Science 316 1491 1493
8. SchunkertHGotzABraundPMcGinnisRTregouetDA 2008 Repeated replication and a prospective meta-analysis of the association between chromosome 9p21.3 and coronary artery disease. Circulation 117 1675 1684
9. AbdullahKGLiLShenGQHuYYangY 2008 Four SNPS on chromosome 9p21 confer risk to premature, familial CAD and MI in an American Caucasian population (GeneQuest). Ann Hum Genet 72 654 657
10. ShenGQLiLRaoSAbdullahKGBanJM 2008 Four SNPs on chromosome 9p21 in a South Korean population implicate a genetic locus that confers high cross-race risk for development of coronary artery disease. Arterioscler Thromb Vasc Biol 28 360 365
11. AssimesTLKnowlesJWBasuAIribarrenCSouthwickA 2008 Susceptibility locus for clinical and subclinical coronary artery disease at chromosome 9p21 in the multi-ethnic ADVANCE study. Hum Mol Genet 17 2320 2328
12. HelgadottirAThorleifssonGMagnussonKPGretarsdottirSSteinthorsdottirV 2008 The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm. Nat Genet 40 217 224
13. SchaeferASRichterGMGroessner-SchreiberBNoackBNothnagelM 2009 Identification of a shared genetic susceptibility locus for coronary heart disease and periodontitis. PLoS Genet 5 e1000378 doi:10.1371/journal.pgen.1000378
14. ManolioTA 2009 Cohort studies and the genetics of complex disease. Nat Genet 41 5 6
15. MenteAde KoningLShannonHSAnandSS 2009 A systematic review of the evidence supporting a causal link between dietary factors and coronary heart disease. Arch Intern Med 169 659 669
16. OrnishDScherwitzLWBillingsJHBrownSEGouldKL 1998 Intensive lifestyle changes for reversal of coronary heart disease. JAMA 280 2001 2007
17. EsselstynCBJr 2001 Resolving the coronary artery disease epidemic through plant-based nutrition. Prev Cardiol 4 171 177
18. OrdovasJMTaiES 2008 Why study gene-environment interactions? Curr Opin Lipidol 19 158 167
19. HardyJSingletonA 2009 Genomewide association studies and human disease. N Engl J Med 360 1759 1768
20. WillettWC 2002 Balancing life-style and genomics research for disease prevention. Science 296 695 698
21. MaherB 2008 Personal genomes: The case of the missing heritability. Nature 456 18 21
22. IqbalRAnandSOunpuuSIslamSZhangX 2008 Dietary patterns and the risk of acute myocardial infarction in 52 countries: results of the INTERHEART study. Circulation 118 1929 1937
23. VartiainenELaatikainenTPeltonenMJuoleviAMannistoS 2009 Thirty-five-year trends in cardiovascular risk factors in Finland. Int J Epidemiol 39 504 518
24. RissanenTHVoutilainenSVirtanenJKVenhoBVanharantaM 2003 Low intake of fruits, berries and vegetables is associated with excess mortality in men: the Kuopio Ischaemic Heart Disease Risk Factor (KIHD) Study. J Nutr 133 199 204
25. WiggintonJECutlerDJAbecasisGR 2005 A note on exact tests of Hardy-Weinberg equilibrium. Am J Hum Genet 76 887 893
26. PurcellSNealeBTodd-BrownKThomasLFerreiraMA 2007 PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 81 559 575
27. BarrettJCFryBMallerJDalyMJ 2005 Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21 263 265
28. AnandSSXieCPareGMontpetitARangarajanS 2009 Genetic variants associated with myocardial infarction risk factors2 in over 8000 individuals from five ethnic groups: the INTERHEART Genetics Study. Circ Cardiovasc Genet 2 16 25
29. JoshiPIslamSPaisPReddySDorairajP 2007 Risk factors for early myocardial infarction in South Asians compared with individuals in other countries. JAMA 297 286 294
30. LanasFAvezumABautistaLEDiazRLunaM 2007 Risk factors for acute myocardial infarction in Latin America: the INTERHEART Latin American study. Circulation 115 1067 1074
31. KarvanenJSilanderKKeeFTiretLSalomaaV 2009 The impact of newly identified loci on coronary heart disease, stroke and total mortality in the MORGAM prospective cohorts. Genet Epidemiol 33 237 246
32. PaynterNPChasmanDIBuringJEShiffmanDCookNR 2009 Cardiovascular disease risk prediction with and without knowledge of genetic variation at chromosome 9p21.3. Ann Intern Med 150 65 72
33. HorneBDCarlquistJFMuhlesteinJBBairTLAndersonJL 2008 Association of variation in the chromosome 9p21 locus with myocardial infarction versus chronic coronary artery disease. Circ Cardiovasc Genet 1 85 92
34. DoriaAWojcikJXuRGervinoEVHauserTH 2008 Interaction between poor glycemic control and 9p21 locus on risk of coronary artery disease in type 2 diabetes. JAMA 300 2389 2397
35. WilliamsDEPrevostATWhichelowMJCoxBDDayNE 2000 A cross-sectional study of dietary patterns with glucose intolerance and other features of the metabolic syndrome. Br J Nutr 83 257 266
36. ViselAZhuYMayDAfzalVGongE 2010 Targeted deletion of the 9p21 non-coding coronary artery disease risk interval in mice. Nature 464 409 412
Štítky
Interné lekárstvoČlánok vyšiel v časopise
PLOS Medicine
2011 Číslo 10
- MUDr. Dana Vondráčková: Hepatopatie sú pri liečbe metamizolom väčším strašiakom ako agranulocytóza
- Metamizol v liečbe pooperačnej bolesti u detí do 6 rokov veku
- Parazitičtí červi v terapii Crohnovy choroby a dalších zánětlivých autoimunitních onemocnění
- Vztah mezi statiny a rizikem vzniku nádorových onemocnění − metaanalýza
- Statiny indukovaná myopatie: Jak na diferenciální diagnostiku?
Najčítanejšie v tomto čísle
- STrengthening the Reporting of OBservational studies in Epidemiology – Molecular Epidemiology (STROBE-ME): An Extension of the STROBE Statement
- The Effect of Chromosome 9p21 Variants on Cardiovascular Disease May Be Modified by Dietary Intake: Evidence from a Case/Control and a Prospective Study
- Universal Definition of Loss to Follow-Up in HIV Treatment Programs: A Statistical Analysis of 111 Facilities in Africa, Asia, and Latin America
- Estimating Infection Attack Rates and Severity in Real Time during an Influenza Pandemic: Analysis of Serial Cross-Sectional Serologic Surveillance Data