Risk of Violent Crime in Individuals with Epilepsy and Traumatic Brain Injury: A 35-Year Swedish Population Study
Background:
Epilepsy and traumatic brain injury are common neurological conditions, with general population prevalence estimates around 0.5% and 0.3%, respectively. Although both illnesses are associated with various adverse outcomes, and expert opinion has suggested increased criminality, links with violent behaviour remain uncertain.
Methods and Findings:
We combined Swedish population registers from 1973 to 2009, and examined associations of epilepsy (n = 22,947) and traumatic brain injury (n = 22,914) with subsequent violent crime (defined as convictions for homicide, assault, robbery, arson, any sexual offense, or illegal threats or intimidation). Each case was age and gender matched with ten general population controls, and analysed using conditional logistic regression with adjustment for socio-demographic factors. In addition, we compared cases with unaffected siblings.
Among the traumatic brain injury cases, 2,011 individuals (8.8%) committed violent crime after diagnosis, which, compared with population controls (n = 229,118), corresponded to a substantially increased risk (adjusted odds ratio [aOR] = 3.3, 95% CI: 3.1–3.5); this risk was attenuated when cases were compared with unaffected siblings (aOR = 2.0, 1.8–2.3). Among individuals with epilepsy, 973 (4.2%) committed a violent offense after diagnosis, corresponding to a significantly increased odds of violent crime compared with 224,006 population controls (aOR = 1.5, 1.4–1.7). However, this association disappeared when individuals with epilepsy were compared with their unaffected siblings (aOR = 1.1, 0.9–1.2). We found heterogeneity in violence risk by age of disease onset, severity, comorbidity with substance abuse, and clinical subgroups. Case ascertainment was restricted to patient registers.
Conclusions:
In this longitudinal population-based study, we found that, after adjustment for familial confounding, epilepsy was not associated with increased risk of violent crime, questioning expert opinion that has suggested a causal relationship. In contrast, although there was some attenuation in risk estimates after adjustment for familial factors and substance abuse in individuals with traumatic brain injury, we found a significantly increased risk of violent crime. The implications of these findings will vary for clinical services, the criminal justice system, and patient charities.
: Please see later in the article for the Editors' Summary
Vyšlo v časopise:
Risk of Violent Crime in Individuals with Epilepsy and Traumatic Brain Injury: A 35-Year Swedish Population Study. PLoS Med 8(12): e32767. doi:10.1371/journal.pmed.1001150
Kategorie:
Research Article
prolekare.web.journal.doi_sk:
https://doi.org/10.1371/journal.pmed.1001150
Souhrn
Background:
Epilepsy and traumatic brain injury are common neurological conditions, with general population prevalence estimates around 0.5% and 0.3%, respectively. Although both illnesses are associated with various adverse outcomes, and expert opinion has suggested increased criminality, links with violent behaviour remain uncertain.
Methods and Findings:
We combined Swedish population registers from 1973 to 2009, and examined associations of epilepsy (n = 22,947) and traumatic brain injury (n = 22,914) with subsequent violent crime (defined as convictions for homicide, assault, robbery, arson, any sexual offense, or illegal threats or intimidation). Each case was age and gender matched with ten general population controls, and analysed using conditional logistic regression with adjustment for socio-demographic factors. In addition, we compared cases with unaffected siblings.
Among the traumatic brain injury cases, 2,011 individuals (8.8%) committed violent crime after diagnosis, which, compared with population controls (n = 229,118), corresponded to a substantially increased risk (adjusted odds ratio [aOR] = 3.3, 95% CI: 3.1–3.5); this risk was attenuated when cases were compared with unaffected siblings (aOR = 2.0, 1.8–2.3). Among individuals with epilepsy, 973 (4.2%) committed a violent offense after diagnosis, corresponding to a significantly increased odds of violent crime compared with 224,006 population controls (aOR = 1.5, 1.4–1.7). However, this association disappeared when individuals with epilepsy were compared with their unaffected siblings (aOR = 1.1, 0.9–1.2). We found heterogeneity in violence risk by age of disease onset, severity, comorbidity with substance abuse, and clinical subgroups. Case ascertainment was restricted to patient registers.
Conclusions:
In this longitudinal population-based study, we found that, after adjustment for familial confounding, epilepsy was not associated with increased risk of violent crime, questioning expert opinion that has suggested a causal relationship. In contrast, although there was some attenuation in risk estimates after adjustment for familial factors and substance abuse in individuals with traumatic brain injury, we found a significantly increased risk of violent crime. The implications of these findings will vary for clinical services, the criminal justice system, and patient charities.
: Please see later in the article for the Editors' Summary
Zdroje
1. FazelSGulatiGLinsellLGeddesJRGrannM 2009 Schizophrenia and violence: systematic review and meta-analysis. PLoS Med 6 e1000120 doi:10.1371/journal.pmed.1000120
2. WallaceCMullenPBurgessPPalmerSRuschenaD 1998 Serious criminal offending and mental disorder. Br J Psychiatry 172 477 484
3. ElliottFA 1992 Violence. The neurologic contribution: an overview. Arch Neurol 49 595 603
4. FilleyCPriceBNellVAntoinetteTMorganA 2001 Toward an understanding of violence: neurobehavioral aspects of unwarranted physical aggression—Aspen Neurobehavioral Conference Consensus Statement. Neuropsychiatry Neuropsychol Behav Neurol 14 1 14
5. MarkusRRonnieDM 2008 Epileptic automatisms in the criminal courts: 13 cases tried in England and Wales between 1975 and 2001. Epilepsia 49 138 145
6. TooneB 2009 Epilepsy. GelderMAndreasenNLopez-IborJGeddesJ The new Oxford textbook of psychiatry, 2nd ed Oxford Oxford University Press 1076 1080
7. TardiffK 2003 Violence. HalesRYudofskyS Textbook of clinical psychiatry, 4th ed Washington (District of Columbia) American Psychiatric Publishing
8. LambertMSchmitzERingHTrimbleMR 2003 Neuropsychiatric aspects of epilepsy. SchifferRRaoSFogelB Neuropsychiatry, 2nd ed Philadelphia Lippincott, Williams & Williams
9. MaudsleyH 1870 Body and mind London Macmillan
10. FazelSPhilipsonJGardinerLMerrittRGrannM 2009 Neurological disorders and violence: a systematic review and meta-analysis with a focus on epilepsy and traumatic brain injury. J Neurol 256 1591 1602
11. WhitmanSColemanTPatmonCDesaiBCohenR 1984 Epilepsy in prisons: elevated prevalence and no relationship to violence. Neurology 34 775 782
12. GunnJBonnJ 1971 Criminality and violence in epileptic prisoners. Br J Psychiatry 118 337 343
13. RantakallioPKoiranenMMottonenJ 1992 Association of perinatal events, epilepsy, and central nervous system trauma with juvenile delinquency. Arch Dis Child 67 1459 1461
14. DamasioHGrabowskiTFrankRGalaburdaADamasioA 1994 The return of Phineas Gage: clues about the brain from the skull of a famous patient. Science 264 1102 1105
15. GrafmanJSchwabKWardenDPridgenABrownHR 1996 Frontal lobe injuries, violence, and aggression: a report of the Vietnam Head Injury Study. Neurology 46 1231 1238
16. BlakePYPincusJHBucknerC 1995 Neurologic abnormalities in murderers. Neurology 45 1641 1647
17. WilliamsWHMewseAJTonksJMillsSBurgessCN 2010 Traumatic brain injury in a prison population: prevalence and risk for re-offending. Brain Inj 24 1184 1188
18. TurkstraLJonesDTolerH 2003 Brain injury and violent crime. Brain Inj 17 39 47
19. AndersonVSpencer-SmithMLeventerRColemanLAndersonP 2009 Childhood brain insult: can age at insult help us predict outcome? Brain 132 45 56
20. AmorosoCZwiASomervilleEGroveN 2006 Epilepsy and stigma. Lancet 367 1143 1144
21. SimpsonGMohrRRedmanA 2000 Cultural variations in the understanding of traumatic brain injury and brain injury rehabilitation. Brain Inj 14 125 140
22. TagliaferriFCompagnoneCKorsicMServadeiFKrausJ 2006 A systematic review of brain injury epidemiology in Europe. Acta Neurochir (Wien) 148 255 268
23. ForsgrenLBeghiEÕunASillanpääM 2005 The epidemiology of epilepsy in Europe—a systematic review. Eur J Neurol 12 245 253
24. ButlerTKariminiaALevyMMurphyM 2004 The self-reported health status of prisoners in New South Wales. Aust N Z J Public Health 28 344 350
25. BrunsJHauserW 2003 The epidemiology of traumatic brain injury: a review. Epilepsia 44 2 10
26. Statistics Sweden 2005 Flergenerationsregistret 2004: En beskrivning av innehåll och kvalitet. [The Multi-Generation Register 2004: a description of content and quality.] Örebro (Sweden) Statistics Sweden
27. Swedish National Board of Health and Welfare 2011 Patientregistret. [Patient Register.] Available: http://www.socialstyrelsen.se/register/halsodataregister/patientregistret. Accessed 21 November 2011
28. HammarNAlfredssonLRosenMSpetzCLKahanT 2001 A national record linkage to study acute myocardial infarction incidence and case fatality in Sweden. Int J Epidemiol 30 Suppl 1 S30 S34
29. GedeborgREngquistHBerglundLMichaelssonK 2008 Identification of incident injuries in Hospital Discharge Registers. Epidemiol 19 860 867
30. LindbladURåstamLRanstamJPetersonM 1993 Validity of register data on acute myocardial infarction and acute stroke: the Skaraborg Hypertension Project. Scand J Soc Med 21 3 9
31. JiangGde Pedro-CuestaJFredriksonS 1995 Guillain-Barré syndrome in south-west Stockholm, 1973–1991, 1. Quality of registered hospital diagnoses and incidence. Acta Neurol Scand 91 109 117
32. EkholmBEkholmAAdolfssonRVaresMÖsbyU 2005 Evaluation of diagnostic procedures in Swedish patients with schizophrenia and related psychoses. Nord J Psychiatry 59 457 464
33. DalmanCBomsJCullbergJAllebeckP 2002 Young cases of schizophrenia identified in a national inpatient register. Are the diagnoses valid? Soc Psychiatry Psychiatr Epidemiol 37 527 531
34. LudvigssonJAnderssonEEkbomAFeychtingMKimJ-L 2011 External review and validation of the Swedish national inpatient register. BMC Public Health 11 450
35. FazelSLångströmNHjernAGrannMLichtensteinP 2009 Schizophrenia, substance abuse, and violent crime. JAMA 301 2016 2023
36. FazelSGrannM 2006 The population impact of severe mental illness on violent crime. Am J Psychiatry 163 1397 1403
37. HjernALindbladFVinnerljungB 2002 Suicide, psychiatric illness, and social maladjustment in intercountry adoptees in Sweden: a cohort study. Lancet 360 443 448
38. QinPXuHLaursenTMVestergaardMMortensenPB 2005 Risk for schizophrenia and schizophrenia-like psychosis among patients with epilepsy: population based cohort study. BMJ 331 23
39. GreveKWSherwinEStanfordMSMathiasCLoveJ 2001 Personality and neurocognitive correlates of impulsive aggression in long-term survivors of severe traumatic brain injury. Brain Inj 15 255 262
40. DyerKFWBellRMcCannJRauchR 2006 Aggression after traumatic brain injury: analysing socially desirable responses and the nature of aggressive traits. Brain Inj 20 1163 1173
41. FazelSLichtensteinPGrannMGoodwinGMLangstromN 2010 Bipolar disorder and violent crime: new evidence from population-based longitudinal studies and systematic review. Arch Gen Psychiatry 67 931 938
42. Klein-GeltinkaJRochonbPDyeraSLaxerbMAndersonG 2007 Readers should systematically assess methods used to identify, measure and analyze confounding in observational cohort studies. J Clin Epidemiol 60 766 772
43. KaleR 1997 Bringing epilepsy out of the shadows. BMJ 315 2 3
44. de BoerHM 2002 “Out of the shadows”: a global campaign against epilepsy. Epilepsia 43 7 8
45. LivingstonS 1964 Epilepsy and murder. JAMA 188 172
46. TreimanD 1986 Epilepsy and violence: medical and legal issues. Epilepsia 27 S77 S104
47. FazelSVassosEDaneshJ 2002 Prevalence of epilepsy in prisoners: systematic review. BMJ 324 1495
48. ShihJJLeslieMazwiTFalcaoGVan GerpenJ 2009 Directed aggressive behavior in frontal lobe epilepsy: a video-EEG and ictal SPECT case study. Neurology 73 1804 1806
49. KreutzerJMarwitzJWitolA 1995 Interrelationships between crime, substance abuse, and aggressive behaviours among persons with traumatic brain injury. Brain Inj 9 757 768
50. TatenoAJorgeRERobinsonRG 2003 Clinical correlates of aggressive behaviour after traumatic brain injury. J Neuropsychiatry Clin Neurosci 15 155 160
51. WoodRLLiossiC 2006 Neuropsychological and neurobehavioral correlates of aggression following traumatic brain injury. J Neuropsychiatry Clin Neurosci 18 333 341
52. BaguleyICooperJFelminghamK 2006 Aggressive behavior following traumatic brain injury: how common is common? J Head Trauma Rehabil 21 45 56
53. DamasioAR 2000 A neural basis for sociopathy. Arch Gen Psychiatry 57 128 129
54. GrahamDPCardonAL 2008 An update on substance use and treatment following traumatic brain injury. Ann N Y Acad Sci 1141 148 162
55. SteinSCDoolinEJ 1995 Management of minor closed head injury in children and adolescents. Pediatric Surg Int 10 465 471
56. RaineAMoffittTECaspiALoeberRStouthamer-LoeberM 2005 Neurocognitive impairments in boys on the life-course persistent antisocial path. J Abnorm Psychol 114 38 49
57. WilliamsHCordanGMewseAJTonksJBurgessC 2010 Self-reported traumatic brain injury in male young offenders: a risk factor for re-offending, poor mental health and violence? Neuropsychol Rehab 20 801 812
58. National Institute for Health and Clinical Excellence 2007 Head injury: triage, assessment, investigation and early management of head injury in infants, children and adults London National Institute for Health and Clinical Excellence
59. Leon-CarrionJRamosF 2003 Blows to the head during development can predispose to violent criminal behaviour: rehabilitation of consequences of head injury is a measure for crime prevention. Brain Inj 17 207 216
60. American Psychiatric Association 2004 Practice guideline for the treatment of patients with schizophrenia Arlington (Virginia) American Psychiatric Association
61. HubandNFerriterMNathanRJonesH 2010 Antiepileptic drugs for treating recurrent aggression. Cochrane Database Syst Rev 2 CD003499 doi:10.1002/14651858.CD003499.pub3
62. ChristensenJVestergaardMMortensenPBSideniusPAgerboE 2007 Epilepsy and risk of suicide: a population-based case-control study. Lancet Neurol 6 693 698
63. ArseneaultLMoffittTCaspiATaylorPSilvaP 2000 Mental disorders and violence in a total birth cohort: results from the Dunedin study. Arch Gen Psychiatry 57 979 986
64. DolménL 2001 Brottsligheten i olika länder. [Criminality in different countries.] Stockholm National Council for Crime Prevention
65. FarringtonDLanganPTonryM 2004 (2004) Cross-national studies in crime and justice Washington (District of Columbia) US Department of Justice, Bureau of Justice Statistics
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