#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Uptake of Home-Based HIV Testing, Linkage to Care, and Community Attitudes about ART in Rural KwaZulu-Natal, South Africa: Descriptive Results from the First Phase of the ANRS 12249 TasP Cluster-Randomised Trial


Collins Iwuji and colleagues report implementation indicators and early health outcomes from the first phase of a cluster-randomized trial of immediate antiretroviral therapy to all HIV-positive individuals in rural KwaZulu-Natal, South Africa.


Vyšlo v časopise: Uptake of Home-Based HIV Testing, Linkage to Care, and Community Attitudes about ART in Rural KwaZulu-Natal, South Africa: Descriptive Results from the First Phase of the ANRS 12249 TasP Cluster-Randomised Trial. PLoS Med 13(8): e32767. doi:10.1371/journal.pmed.1002107
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pmed.1002107

Souhrn

Collins Iwuji and colleagues report implementation indicators and early health outcomes from the first phase of a cluster-randomized trial of immediate antiretroviral therapy to all HIV-positive individuals in rural KwaZulu-Natal, South Africa.


Zdroje

1. Joint United Nations Programme on HIV/AIDS. The gap report. 2014 [cited 11 Jun 2015]. Available: http://www.unaids.org/sites/default/files/en/media/unaids/contentassets/documents/unaidspublication/2014/UNAIDS_Gap_report_en.pdf.

2. Joint United Nations Programme on HIV/AIDS. How AIDS changed everything. MDG 6: 15 years, 15 lessons of hope from the AIDS response. 2015 [cited 15 Oct 2015]. Available: http://www.unaids.org/sites/default/files/media_asset/MDG6Report_en.pdf.

3. Tanser F, Barnighausen T, Grapsa E, Zaidi J, Newell ML. High coverage of ART associated with decline in risk of HIV acquisition in rural KwaZulu-Natal, South Africa. Science. 2013;339:966–971. doi: 10.1126/science.1228160 23430656

4. Quinn TC, Wawer MJ, Sewankambo N, Serwadda D, Li C, Wabwire-Mangen F, et al. Viral load and heterosexual transmission of human immunodeficiency virus type 1. Rakai Project Study Group. N Engl J Med. 2000;342:921–929. 10738050

5. Cohen MS, Chen YQ, McCauley M, Gamble T, Hosseinipour MC, Kumarasamy N, et al. Prevention of HIV-1 infection with early antiretroviral therapy. N Engl J Med. 2011;365:493–505. doi: 10.1056/NEJMoa1105243 21767103

6. Granich RM, Gilks CF, Dye C, De Cock KM, Williams BG. Universal voluntary HIV testing with immediate antiretroviral therapy as a strategy for elimination of HIV transmission: a mathematical model. Lancet. 2009;373:48–57. doi: 10.1016/S0140-6736(08)61697-9 19038438

7. Joint United Nations Programme on HIV/AIDS. 90-90-90: an ambitious treatment target to help end the AIDS epidemic. 2014 [cited 22 Jan 2015]. Available: http://www.unaids.org/sites/default/files/media_asset/90-90-90_en_0.pdf.

8. Eaton JW, Johnson LF, Salomon JA, Barnighausen T, Bendavid E, Bershteyn A, et al. HIV treatment as prevention: systematic comparison of mathematical models of the potential impact of antiretroviral therapy on HIV incidence in South Africa. PLoS Med. 2012;9:e1001245. doi: 10.1371/journal.pmed.1001245 22802730

9. Dodd PJ, Garnett GP, Hallett TB. Examining the promise of HIV elimination by ‘test and treat’ in hyperendemic settings. AIDS. 2010;24:729–735. doi: 10.1097/QAD.0b013e32833433fe 20154580

10. Hontelez JA, Lurie M, Bärnighausen T, Bakker R, Baltussen R, Tanser F, et al. Elimination of HIV in South Africa through expanded access to antiretroviral therapy: a model comparison study. PLoS Med. 2013;10:e1001534. doi: 10.1371/journal.pmed.1001534 24167449

11. Iwuji C, McGrath N, de Oliveira T, Porter K, Pillay D, Fisher M, et al. The art of HIV elimination: past and present science. J AIDS Clin Res. 2015;6:525.

12. Suthar AB, Ford N, Bachanas PJ, Wong VJ, Rajan JS, Saltzman AK, et al. Towards universal voluntary HIV testing and counselling: a systematic review and meta-analysis of community-based approaches. PLoS Med. 2013;10:e1001496. doi: 10.1371/journal.pmed.1001496 23966838

13. Obare F, Fleming P, Anglewicz P, Thornton R, Martinson F, Kapatuka A, et al. Acceptance of repeat population-based voluntary counselling and testing for HIV in rural Malawi. Sex Transm Infect. 2009;85:139–144. doi: 10.1136/sti.2008.030320 18927181

14. Mugglin C, Estill J, Wandeler G, Bender N, Egger M, Gsponer T, et al. Loss to programme between HIV diagnosis and initiation of antiretroviral therapy in sub-Saharan Africa: systematic review and meta-analysis. Trop Med Int Health. 2012;17:1509–1520. doi: 10.1111/j.1365-3156.2012.03089.x 22994151

15. Choko AT, MacPherson P, Webb EL, Willey BA, Feasy H, Sambakunsi R, et al. Uptake, accuracy, safety, and linkage into care over two years of promoting annual self-testing for HIV in Blantyre, Malawi: a community-based prospective study. PLoS Med. 2015;12:e1001873. doi: 10.1371/journal.pmed.1001873 26348035

16. Curran K, Ngure K, Shell-Duncan B, Vusha S, Mugo NR, Heffron R, et al. ‘If I am given antiretrovirals I will think I am nearing the grave’: Kenyan HIV serodiscordant couples’ attitudes regarding early initiation of antiretroviral therapy. AIDS. 2014;28:227–233. doi: 10.1097/QAD.0000000000000025 24413310

17. Fowler N, Arkell P, Abouyannis M, James C, Roberts L. Attitudes of serodiscordant couples towards antiretroviral-based HIV prevention strategies in Kenya: a qualitative study. AIDS Patient Care STDS. 2015;29:33–42. doi: 10.1089/apc.2014.0210 25375792

18. Hayes R, Ayles H, Beyers N, Sabapathy K, Floyd S, Shanaube K, et al. HPTN 071 (PopART): rationale and design of a cluster-randomised trial of the population impact of an HIV combination prevention intervention including universal testing and treatment—a study protocol for a cluster randomised trial. Trials. 2014;15:57. doi: 10.1186/1745-6215-15-57 24524229

19. AVAC, Joint United Nations Programme on HIV/AIDS. Antiretroviral treatment for prevention of HIV and tuberculosis: 2013 update on current and planned research efforts. 2014 Apr [cited 5 Feb 2015]. Available: http://www.avac.org/sites/default/files/resource-files/ART%20for%20prevention%20study%20update%20report%20March%202014.pdf.

20. Iwuji CC, Orne-Gliemann J, Tanser F, Boyer S, Lessells RJ, Lert F, et al. Evaluation of the impact of immediate versus WHO recommendations-guided antiretroviral therapy initiation on HIV incidence: the ANRS 12249 TasP (Treatment as Prevention) trial in Hlabisa sub-district, KwaZulu-Natal, South Africa: study protocol for a cluster randomised controlled trial. Trials. 2013;14:230. doi: 10.1186/1745-6215-14-230 23880306

21. Houlihan CF, Bland RM, Mutevedzi PC, Lessells RJ, Ndirangu J, Thulare H, et al. Cohort profile: Hlabisa HIV treatment and care programme. Int J Epidemiol. 2011;40:318–326. doi: 10.1093/ije/dyp402 20154009

22. Orne-Gliemann J, Larmarange J, Boyer S, Iwuji C, McGrath N, Barnighausen T, et al. Addressing social issues in a universal HIV test and treat intervention trial (ANRS 12249 TasP) in South Africa: methods for appraisal. BMC Public Health. 2015;15:209. doi: 10.1186/s12889-015-1344-y 25880823

23. World Health Organization. Module 4: HIV testing strategies and algorithms. 2005 [cited 21 Feb 2016]. Available: http://www.who.int/diagnostics_laboratory/documents/guidance/pm_module4.pdf.

24. Rao JNK, Scott AJ. On chi-squared tests for multiway contigency tables with proportions estimated from survey data. Ann Stat. 1984;12:46–60.

25. Thomas DR, Rao JNK. Small-sample comparison of level and power for simple goodness-of-fit statistics under cluster sampling. J Am Stat Assoc. 1990;82:630–636.

26. World Health Organization. Guideline on when to start antiretroviral therapy and on pre-exposure prophylaxis to ART. 2015 Sep [cited 15 Oct 2015]. Available: http://apps.who.int/iris/bitstream/10665/186275/1/9789241509565_eng.pdf?ua=1.

27. Maheswaran H, Thulare H, Stanistreet D, Tanser F, Newell ML. Starting a home and mobile HIV testing service in a rural area of South Africa. J Acquir Immune Defic Syndr. 2012;59:e43–e46. doi: 10.1097/QAI.0b013e3182414ed7 22107821

28. Labhardt ND, Motlomelo M, Cerutti B, Pfeiffer K, Kamele M, Hobbins MA, et al. Home-based versus mobile clinic HIV testing and counseling in rural Lesotho: a cluster-randomized trial. PLoS Med. 2014;11:e1001768. doi: 10.1371/journal.pmed.1001768 25513807

29. Coates TJ, Kulich M, Celentano DD, Zelaya CE, Chariyalertsak S, Chingono A, et al. Effect of community-based voluntary counselling and testing on HIV incidence and social and behavioural outcomes (NIMH Project Accept; HPTN 043): a cluster-randomised trial. Lancet Glob Health. 2014;2:e267–e277. doi: 10.1016/S2214-109X(14)70032-4 25103167

30. Kranzer K, Govindasamy D, Ford N, Johnston V, Lawn SD. Quantifying and addressing losses along the continuum of care for people living with HIV infection in sub-Saharan Africa: a systematic review. J Int AIDS Soc. 2012;15:17383. doi: 10.7448/IAS.15.2.17383 23199799

31. Katz IT, Essien T, Marinda ET, Gray GE, Bangsberg DR, Martinson NA, et al. Antiretroviral therapy refusal among newly diagnosed HIV-infected adults. AIDS. 2011;25:2177–2181. doi: 10.1097/QAD.0b013e32834b6464 21832935

32. INSIGHT START Study Group, Lundgren JD, Babiker AG, Gordin F, Emery S, Grund B, et al. Initiation of antiretroviral therapy in early asymptomatic HIV infection. N Engl J Med. 2015;373:795–807. doi: 10.1056/NEJMoa1506816 26192873

33. TEMPRANO ANRS 12136 Study Group, Danel C, Moh R, Gabillard D, Badje A, Le Carrou J, et al. A trial of early antiretrovirals and isoniazid preventive therapy in Africa. N Engl J Med. 2015;373:808–822. doi: 10.1056/NEJMoa1507198 26193126

Štítky
Interné lekárstvo

Článok vyšiel v časopise

PLOS Medicine


2016 Číslo 8
Najčítanejšie tento týždeň
Najčítanejšie v tomto čísle
Kurzy

Zvýšte si kvalifikáciu online z pohodlia domova

Aktuální možnosti diagnostiky a léčby litiáz
nový kurz
Autori: MUDr. Tomáš Ürge, PhD.

Všetky kurzy
Prihlásenie
Zabudnuté heslo

Zadajte e-mailovú adresu, s ktorou ste vytvárali účet. Budú Vám na ňu zasielané informácie k nastaveniu nového hesla.

Prihlásenie

Nemáte účet?  Registrujte sa

#ADS_BOTTOM_SCRIPTS#