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A novel electronic algorithm using host biomarker point-of-care tests for the management of febrile illnesses in Tanzanian children (e-POCT): A randomized, controlled non-inferiority trial


In a randomized controlled non-inferiority trial, Kristina Keitel and colleagues compare the use of an electronic algorithm using host biomarker point-of-care-tests to routine care for the management of febrile illnesses in Tanzanian children.


Vyšlo v časopise: A novel electronic algorithm using host biomarker point-of-care tests for the management of febrile illnesses in Tanzanian children (e-POCT): A randomized, controlled non-inferiority trial. PLoS Med 14(10): e32767. doi:10.1371/journal.pmed.1002411
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pmed.1002411

Souhrn

In a randomized controlled non-inferiority trial, Kristina Keitel and colleagues compare the use of an electronic algorithm using host biomarker point-of-care-tests to routine care for the management of febrile illnesses in Tanzanian children.


Zdroje

1. Burton DC, Flannery B, Onyango B, Larson C, Alaii J, Zhang X, et al. Healthcare-seeking behaviour for common infectious disease-related illnesses in rural Kenya: a community-based house-to-house survey. J Heal Popul Nutr. 2011;29:61–70. doi: 10.3329/jhpn.v29i1.7567

2. Shao AF, Rambaud-Althaus C, Samaka J, Faustine AF, Perri-Moore S, Swai N, et al. New algorithm for managing childhood illness using mobile technology (ALMANACH): a controlled non-inferiority study on clinical outcome and antibiotic use in Tanzania. PLoS ONE. 2015;10:e0132316. doi: 10.1371/journal.pone.0132316 26161535

3. Liu L, Oza S, Hogan D, Perin J, Rudan I, Lawn JE, et al. Global, regional, and national causes of child mortality in 2000–13, with projections to inform post-2015 priorities: an updated systematic analysis. Lancet. 2014;385:430–40. doi: 10.1016/S0140-6736(14)61698-6 25280870

4. Risk R, Naismith H, Burnett A, Moore SE, Cham M, Unger S. Rational prescribing in paediatrics in a resource-limited setting. Arch Dis Child. 2013;98:503–9. doi: 10.1136/archdischild-2012-302987 23661572

5. Okeke IN, Laxminarayan R, Bhutta ZA, Duse AG, Jenkins P, O’Brien TF, et al. Antimicrobial resistance in developing countries. Part I: recent trends and current status. Lancet Infect Dis. 2005;5:481–93. doi: 10.1016/S1473-3099(05)70189-4 16048717

6. Horwood C, Butler LM, Vermaak K, Rollins N, Haskins L, Nkosi P, et al. Disease profile of children under 5 years attending primary health care clinics in a high HIV prevalence setting in South Africa. Trop Med Int Health. 2011;16:42–52. doi: 10.1111/j.1365-3156.2010.02672.x 21091856

7. World Health Organization. IMCI chart booklet. Geneva: World Health Organization; 2014 [cited 2017 Sep 22]. Available: http://www.who.int/maternal_child_adolescent/documents/IMCI_chartbooklet/en/.

8. Gera T, Shah D, Garner P, Richardson M, Sachdev HS. Integrated management of childhood illness (IMCI) strategy for children under five. Cochrane Database Syst Rev. 2016;6:CD010123. doi: 10.1002/14651858.CD010123.pub2 27378094

9. Horwood C, Vermaak K, Rollins N, Haskins L, Nkosi P, Qazi S. An evaluation of the quality of IMCI assessments among IMCI trained health workers in South Africa. PLoS ONE. 2009;4:e5937. doi: 10.1371/journal.pone.0005937 19536288

10. Baiden F, Owusu-Agyei S, Bawah J, Bruce J, Tivura M, Delmini R, et al. An evaluation of the clinical assessments of under-five febrile children presenting to primary health facilities in rural Ghana. PLoS ONE. 2011;6:e28944. doi: 10.1371/journal.pone.0028944 22174932

11. Arifeen SE, Bryce J, Gouws E, Baqui AH, Black RE, Hoque DME, et al. Quality of care for under-fives in first-level health facilities in one district of Bangladesh. Bull World Health Organ. 2005;83:260–7. /S0042-96862005000400009 doi: S0042-96862005000400009 15868016

12. Mitchell M, Hedt-Gauthier BL, Msellemu D, Nkaka M, Lesh N. Using electronic technology to improve clinical care—results from a before-after cluster trial to evaluate assessment and classification of sick children according to Integrated Management of Childhood Illness (IMCI) protocol in Tanzania. BMC Med Inform Decis Mak. 2013;13:95. doi: 10.1186/1472-6947-13-95 23981292

13. D’Acremont V, Kahama-Maro J, Swai N, Mtasiwa D, Genton B, Lengeler C. Reduction of anti-malarial consumption after rapid diagnostic tests implementation in Dar es Salaam: a before-after and cluster randomized controlled study. Malar J. 2011;10:107. doi: 10.1186/1475-2875-10-107 21529365

14. Rambaud-Althaus C, Shao AF, Kahama-Maro J, Genton B, D’Acremont V. Managing the sick child in the era of declining malaria transmission: development of ALMANACH, an electronic algorithm for appropriate use of antimicrobials. PLoS ONE. 2015;10:e0127674. doi: 10.1371/journal.pone.0127674 26161753

15. D’Acremont V, Kilowoko M, Kyungu E, Philipina S, Sangu W, Kahama-Maro J, et al. Beyond malaria—causes of fever in outpatient Tanzanian children. N Engl J Med. 2014;370:809–17. doi: 10.1056/NEJMoa1214482 24571753

16. Thompson M, Van den Bruel A, Verbakel J, Lakhanpaul M, Haj-Hassan T, Stevens R, et al. Systematic review and validation of prediction rules for identifying children with serious infections in emergency departments and urgent-access primary care. Health Technol Assess. 2012;16:1–100. doi: 10.3310/hta16150 22452986

17. Van den Bruel A, Thompson MJ, Haj-Hassan T, Stevens R, Moll H, Lakhanpaul M, et al. Diagnostic value of laboratory tests in identifying serious infections in febrile children: systematic review. BMJ. 2011;342:d3082. doi: 10.1136/bmj.d3082 21653621

18. Do NTT, Ta NTD, Tran NTH, Than HM, Vu BTN, Hoang LB, et al. Point-of-care C-reactive protein testing to reduce inappropriate use of antibiotics for non-severe acute respiratory infections in Vietnamese primary health care: a randomised controlled trial. Lancet Glob Heal. 2016;4:e633–41. doi: 10.1016/S2214-109X(16)30142-5 27495137

19. Thompson M, Harnden A, Perera R, Mayon-White R, Smith L, McLeod D, et al. Deriving temperature and age appropriate heart rate centiles for children with acute infections. Arch Dis Child. 2009;94:361–5. doi: 10.1136/adc.2008.145011 19019883

20. Nijman RG, Thompson M, van Veen M, Perera R, Moll HA, Oostenbrink R. Derivation and validation of age and temperature specific reference values and centile charts to predict lower respiratory tract infection in children with fever: prospective observational study. BMJ. 2012;345:e4224. doi: 10.1136/bmj.e4224 22761088

21. Cummings P. Methods for estimating adjusted risk ratios. Stata J. 2009;9:175–96.

22. World Health Organization. WHO child growth standards. Geneva: World Health Organization; 2006.

23. Hazir T, Nisar YB, Abbasi S, Ashraf YP, Khurshid J, Tariq P, et al. Comparison of oral amoxicillin with placebo for the treatment of world health organization-defined nonsevere pneumonia in children aged 2–59 months: a multicenter, double-blind, randomized, placebo-controlled trial in pakistan. Clin Infect Dis. 2011;52:293–300. doi: 10.1093/cid/ciq142 21189270

24. Fox MP, Thea DM, Sadruddin S, Bari A, Bonawitz R, Hazir T, et al. Low rates of treatment failure in children aged 2–59 months treated for severe pneumonia: a multisite pooled analysis. Clin Infect Dis. 2013;56:978–87. doi: 10.1093/cid/cis1201 23264361

25. Thompson M, Vodicka TA, Blair PS, Buckley DI, Heneghan C, Hay AD. Duration of symptoms of respiratory tract infections in children: systematic review. BMJ. 2013;347:f7027. doi: 10.1136/bmj.f7027 24335668

26. Begovac J, Soldo I, Presecki V. Cytomegalovirus mononucleosis in children compared with the infection in adults and with Epstein-Barr virus mononucleosis. J Infect. 1988;17:121–5. doi: 10.1016/S0163-4453(88)91571-X 2846703

27. Aabenhus R, Jensen JU, Jorgensen KJ, Hrobjartsson A, Bjerrum L. Biomarkers as point-of-care tests to guide prescription of antibiotics in patients with acute respiratory infections in primary care. Cochrane Database Syst Rev. 2014;11:CD010130. doi: 10.1002/14651858.CD010130.pub2 25374293

28. Burkhardt O, Ewig S, Haagen U, Giersdorf S, Hartmann O, Wegscheider K, et al. Procalcitonin guidance and reduction of antibiotic use in acute respiratory tract infection. Eur Respir J. 2010;36:601–7. doi: 10.1183/09031936.00163309 20185423

29. Schuetz P, Briel M, Mueller B. Clinical outcomes associated with procalcitonin algorithms to guide antibiotic therapy in respiratory tract infections. JAMA. 2013;309:717–8. doi: 10.1001/jama.2013.697 23423417

30. Cals JWL, Butler CC, Hopstaken RM, Hood K, Dinant G-J. Effect of point of care testing for C reactive protein and training in communication skills on antibiotic use in lower respiratory tract infections: cluster randomised trial. BMJ. 2009;338:b1374. doi: 10.1136/bmj.b1374 19416992

31. Lubell Y, Blacksell SD, Dunachie S, Tanganuchitcharnchai A, Althaus T, Watthanaworawit W, et al. Performance of C-reactive protein and procalcitonin to distinguish viral from bacterial and malarial causes of fever in Southeast Asia. BMC Infect Dis. 2015;15:511. doi: 10.1186/s12879-015-1272-6 26558692

32. Erdman LK, D’Acremont V, Hayford K, Rajwans N, Kilowoko M, Kyungu E, et al. Biomarkers of host response predict primary end-point radiological pneumonia in Tanzanian children with clinical pneumonia: a prospective cohort study. PLoS ONE. 2015;10:e0137592. doi: 10.1371/journal.pone.0137592 26366571

33. Verbakel JY, Lemiengre MB, De Burghgraeve T, De Sutter A, Aertgeerts B, Shinkins B, et al. Should all acutely ill children in primary care be tested with point-of-care CRP: a cluster randomised trial. BMC Med. 2016;14:131. doi: 10.1186/s12916-016-0679-2 27716201

34. Enoch AJ, English M, Shepperd S. Does pulse oximeter use impact health outcomes? A systematic review. Arch Dis Child. 2016;101(8):694–700. doi: 10.1136/archdischild-2015-309638 26699537

35. Chalco JP, Huicho L, Alamo C, Carreazo NY, Bada CA. Accuracy of clinical pallor in the diagnosis of anaemia in children: a meta-analysis. BMC Pediatr. 2005;5:46. doi: 10.1186/1471-2431-5-46 16336667

36. Calis JCJ, Phiri KS, Faragher EB, Brabin BJ, Bates I, Cuevas LE, et al. Severe anemia in Malawian children. N Engl J Med. 2008;358:888–99. doi: 10.1056/NEJMoa072727 18305266

37. Brabin BJ, Premji Z, Verhoeff F. An analysis of anemia and child mortality. J Nutr. 2001;131:636S–45S. 11160595

38. Gowraiah V, Awasthi S, Kapoor R, Sahana D, Venkatesh P, Gangadhar B, et al. Can we distinguish pneumonia from wheezy diseases in tachypnoeic children under low-resource conditions? A prospective observational study in four Indian hospitals. Arch Dis Child. 2014;99:899–906. doi: 10.1136/archdischild-2013-305740 24925892

39. Jain DL, Sarathi V, Jawalekar S. Predictors of treatment failure in hospitalized children [3–59 months] with severe and very severe pneumonia. Indian Pediatr. 2013;50:787–9. doi: 10.1007/s13312-013-0220-z 23585421

40. Reed C, Madhi SA, Klugman KP, Kuwanda L, Ortiz JR, Finelli L, et al. Development of the Respiratory Index of Severity in Children (RISC) score among young children with respiratory infections in South Africa. PLoS ONE. 2012;7:e27793. doi: 10.1371/journal.pone.0027793 22238570

41. English M, Esamai F, Wasunna A, Were F, Ogutu B, Wamae A, et al. Assessment of inpatient paediatric care in first referral level hospitals in 13 districts in Kenya. Lancet 2004;363:1948–53. doi: 10.1016/S0140-6736(04)16408-8 15194254

42. Naik P, Voller A. Serum C-reactive protein levels and falciparum malaria. Trans R Soc Trop Med Hyg. 1984;78:812–3. doi: 10.1016/0035-9203(84)90027-0 6398534

43. Church J, Maitland K. Invasive bacterial co-infection in African children with Plasmodium falciparum malaria: a systematic review. BMC Med. 2014;12:31. doi: 10.1186/1741-7015-12-31 24548672

44. Lim Y-W, Steinhoff M, Girosi F, Holtzman D, Campbell H, Boer R, et al. Reducing the global burden of acute lower respiratory infections in children: the contribution of new diagnostics. Nature. 2006;444(Suppl 1):9–18. doi: 10.1038/nature05442 17159890

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