A Cardinal Role for Cathepsin D in Co-Ordinating the Host-Mediated Apoptosis of Macrophages and Killing of Pneumococci

1. MosserDM

EdwardsJP

2008 Exploring the full spectrum of macrophage activation. Nat Rev Immunol 8 958 969

2. SibilleY

ReynoldsHY

1990 Macrophages and polymorphonuclear neutrophils in lung defense and injury. Am Rev Respir Dis 141 471 501

3. ZhangP

SummerWR

BagbyGJ

NelsonS

2000 Innate immunity and pulmonary host defense. Immunol Rev 173 39 51

4. Matute-BelloG

LeeJS

FrevertCW

LilesWC

SutliefS

2004 Optimal timing to repopulation of resident alveolar macrophages with donor cells following total body irradiation and bone marrow transplantation in mice. J Immunol Methods 292 25 34

5. MurphyJ

SummerR

WilsonAA

KottonDN

FineA

2008 The prolonged life-span of alveolar macrophages. Am J Respir Cell Mol Biol 38 380 385

6. LabbeK

SalehM

2008 Cell death in the host response to infection. Cell Death Differ 15 1339 1349

7. de RouxA

MarcosMA

GarciaE

MensaJ

EwigS

2004 Viral community-acquired pneumonia in nonimmunocompromised adults. Chest 125 1343 1351

8. DockrellDH

MarriottHM

PrinceLR

RidgerVC

IncePG

2003 Alveolar macrophage apoptosis contributes to pneumococcal clearance in a resolving model of pulmonary infection. J Immunol 171 5380 5388

9. KnappS

LeemansJC

FlorquinS

BrangerJ

MarisNA

2003 Alveolar macrophages have a protective antiinflammatory role during murine pneumococcal pneumonia. Am J Respir Crit Care Med 167 171 179

10. AliF

LeeME

IannelliF

PozziG

MitchellTJ

2003 Streptococcus pneumoniae-Associated Human Macrophage Apoptosis after Bacterial Internalization via Complement and Fcgamma Receptors Correlates with Intracellular Bacterial Load. J Infect Dis 188 1119 1131

11. LiuH

PerlmanH

PagliariLJ

PopeRM

2001 Constitutively activated Akt-1 is vital for the survival of human monocyte-differentiated macrophages. Role of Mcl-1, independent of nuclear factor (NF)-kappaB, Bad, or caspase activation. J Exp Med 194 113 126

12. MarriottHM

BingleCD

ReadRC

BraleyKE

KroemerG

2005 Dynamic changes in Mcl-1 expression regulate macrophage viability or commitment to apoptosis during bacterial clearance. J Clin Invest 115 359 368

13. SchubertKM

DuronioV

2001 Distinct roles for extracellular-signal-regulated protein kinase (ERK) mitogen-activated protein kinases and phosphatidylinositol 3-kinase in the regulation of Mcl-1 synthesis. Biochem J 356 473 480

14. CuconatiA

MukherjeeC

PerezD

WhiteE

2003 DNA damage response and MCL-1 destruction initiate apoptosis in adenovirus-infected cells. Genes Dev 17 2922 2932

15. NijhawanD

FangM

TraerE

ZhongQ

GaoW

2003 Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation. Genes Dev 17 1475 1486

16. ZhongQ

GaoW

DuF

WangX

2005 Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis. Cell 121 1085 1095

17. HerrantM

JacquelA

MarchettiS

BelhaceneN

ColosettiP

2004 Cleavage of Mcl-1 by caspases impaired its ability to counteract Bim-induced apoptosis. Oncogene 23 7863 7873

18. DockrellDH

LeeM

LynchDH

ReadRC

2001 Immune-mediated phagocytosis and killing of Streptococcus pneumoniae are associated with direct and bystander macrophage apoptosis. J Infect Dis 184 713 722

19. GordonSB

IrvingGR

LawsonRA

LeeME

ReadRC

2000 Intracellular trafficking and killing of Streptococcus pneumoniae by human alveolar macrophages are influenced by opsonins. Infect Immun 68 2286 2293

20. BoyaP

AndreauK

PoncetD

ZamzamiN

PerfettiniJL

2003 Lysosomal membrane permeabilization induces cell death in a mitochondrion-dependent fashion. J Exp Med 197 1323 1334

21. MacleanKH

DorseyFC

ClevelandJL

KastanMB

2008 Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis. J Clin Invest 118 79 88

22. BenesP

VetvickaV

FusekM

2008 Cathepsin D—many functions of one aspartic protease. Crit Rev Oncol Hematol 68 12 28

23. BidereN

LorenzoHK

CarmonaS

LaforgeM

HarperF

2003 Cathepsin D triggers Bax activation, resulting in selective apoptosis-inducing factor (AIF) relocation in T lymphocytes entering the early commitment phase to apoptosis. J Biol Chem 278 31401 31411

24. BlomgranR

ZhengL

StendahlO

2007 Cathepsin-cleaved Bid promotes apoptosis in human neutrophils via oxidative stress-induced lysosomal membrane permeabilization. J Leukoc Biol 81 1213 1223

25. Droga-MazovecG

BojicL

PetelinA

IvanovaS

RomihR

2008 Cysteine cathepsins trigger caspase-dependent cell death through cleavage of bid and antiapoptotic Bcl-2 homologues. J Biol Chem 283 19140 19150

26. HeinrichM

NeumeyerJ

JakobM

HallasC

TchikovV

2004 Cathepsin D links TNF-induced acid sphingomyelinase to Bid-mediated caspase-9 and -3 activation. Cell Death Differ 11 550 563

27. ConusS

PerozzoR

ReinheckelT

PetersC

ScapozzaL

2008 Caspase-8 is activated by cathepsin D initiating neutrophil apoptosis during the resolution of inflammation. J Exp Med 205 685 698

28. DaigneaultM

PrestonJA

MarriottHM

WhyteMK

DockrellDH

2010 The identification of markers of macrophage differentiation in PMA-stimulated THP-1 cells and monocyte-derived macrophages. PLoS One 5 e8668

29. Gyrd-HansenM

FarkasT

FehrenbacherN

BastholmL

Hoyer-HansenM

2006 Apoptosome-independent activation of the lysosomal cell death pathway by caspase-9. Mol Cell Biol 26 7880 7891

30. ChenCS

ChenWN

ZhouM

ArttamangkulS

HauglandRP

2000 Probing the cathepsin D using a BODIPY FL-pepstatin A: applications in fluorescence polarization and microscopy. J Biochem Biophys Methods 42 137 151

31. KatoT

KojimaK

MurachiT

1972 Proteases of macrophages in rat peritoneal exudate, with special reference to the effects of actinomycete protease inhibitors. Biochim Biophys Acta 289 187 193

32. JonssonS

MusherDM

ChapmanA

GoreeA

LawrenceEC

1985 Phagocytosis and killing of common bacterial pathogens of the lung by human alveolar macrophages. J Infect Dis 152 4 13

33. CoakleyRJ

TaggartC

McElvaneyNG

O'NeillSJ

2002 Cytosolic pH and the inflammatory microenvironment modulate cell death in human neutrophils after phagocytosis. Blood 100 3383 3391

34. Rojas-EspinosaO

DannenbergAMJr

MurphyPA

StraatPA

HuangPC

1973 Purification and properties of the cathepsin D types proteinase from beef and rabbit lung and its identification in macrophages. Infect Immun 8 1000 1008

35. WoessnerJFJr

1992 Role of cellular proteinases and their protein inhibitors in inflammation.

WhicherJT

EvansSW

Biochemistry of inflammation Hingham Kluwer academic publishers 57 90

36. ShieldsPP

GonzalesTA

CharlesD

GilliganJP

SternW

1991 Accumulation of pepstatin in cultured endothelial cells and its effect on endothelial processing. Biochem Biophys Res Commun 177 1006 1012

37. FergusonJB

AndrewsJR

VoynickIM

FrutonJS

1973 The specificity of cathepsin D. J Biol Chem 248 6701 6708

38. StankiewiczAR

LivingstoneAM

MohseniN

MosserDD

2009 Regulation of heat-induced apoptosis by Mcl-1 degradation and its inhibition by Hsp70. Cell Death Differ 16 638 647

39. TuloneC

UchiyamaY

NovelliM

GrosvenorN

SaftigP

2007 Haematopoietic development and immunological function in the absence of cathepsin D. BMC Immunol 8 22

40. OjieloCI

CookeK

MancusoP

StandifordTJ

OlkiewiczKM

2003 Defective phagocytosis and clearance of Pseudomonas aeruginosa in the lung following bone marrow transplantation. J Immunol 171 4416 4424

41. MarriottHM

HellewellPG

WhyteMK

DockrellDH

2007 Contrasting roles for reactive oxygen species and nitric oxide in the innate response to pulmonary infection with Streptococcus pneumoniae. Vaccine 25 2485 2490

42. DallaireF

OuelletN

BergeronY

TurmelV

GauthierMC

2001 Microbiological and inflammatory factors associated with the development of pneumococcal pneumonia. J Infect Dis 184 292 300

43. JonesMR

SimmsBT

LupaMM

KoganMS

MizgerdJP

2005 Lung NF-kappaB activation and neutrophil recruitment require IL-1 and TNF receptor signaling during pneumococcal pneumonia. J Immunol 175 7530 7535

44. HerboldW

MausR

HahnI

DingN

SrivastavaM

2010 Importance of CXC chemokine receptor 2 in alveolar neutrophil and exudate macrophage recruitment in response to pneumococcal lung infection. Infect Immun 78 2620 2630

45. MarksM

BurnsT

AbadiM

SeyoumB

ThorntonJ

2007 Influence of neutropenia on the course of serotype 8 pneumococcal pneumonia in mice. Infect Immun 75 1586 1597

46. DeissLP

GalinkaH

BerissiH

CohenO

KimchiA

1996 Cathepsin D protease mediates programmed cell death induced by interferon-gamma, Fas/APO-1 and TNF-alpha. EMBO J 15 3861 3870

47. KagedalK

JohanssonU

OllingerK

2001 The lysosomal protease cathepsin D mediates apoptosis induced by oxidative stress. FASEB J 15 1592 1594

48. MarriottHM

AliF

ReadRC

MitchellTJ

WhyteMK

2004 Nitric oxide levels regulate macrophage commitment to apoptosis or necrosis during pneumococcal infection. FASEB J 18 1126 1128

49. MarriottHM

JacksonLE

WilkinsonTS

SimpsonAJ

MitchellTJ

2008 Reactive oxygen species regulate neutrophil recruitment and survival in pneumococcal pneumonia. Am J Respir Crit Care Med 177 887 895

50. GiddingsKS

ZhaoJ

SimsPJ

TwetenRK

2004 Human CD59 is a receptor for the cholesterol-dependent cytolysin intermedilysin. Nat Struct Mol Biol 11 1173 1178

51. MalleyR

HennekeP

MorseSC

CieslewiczMJ

LipsitchM

2003 Recognition of pneumolysin by Toll-like receptor 4 confers resistance to pneumococcal infection. Proc Natl Acad Sci U S A 100 1966 1971

52. Carrasco-MarinE

Madrazo-TocaF

de Los ToyosJR

Cacho-AlonsoE

TobesR

2009 The innate immunity role of cathepsin-D is linked to Trp-491 and Trp-492 residues of listeriolysin O. Mol Microbiol

53. GuicciardiME

LeistM

GoresGJ

2004 Lysosomes in cell death. Oncogene 23 2881 2890

54. JinM

OpalekJM

MarshCB

WuHM

2004 Proteome comparison of alveolar macrophages with monocytes reveals distinct protein characteristics. Am J Respir Cell Mol Biol 31 322 329

55. CohnZA

FedorkoME

HirschJG

1966 The in vitro differentiation of mononuclear phagocytes. V. The formation of macrophage lysosomes. J Exp Med 123 757 766

56. KozielJ

Maciag-GudowskaA

MikolajczykT

BzowskaM

SturdevantDE

2009 Phagocytosis of Staphylococcus aureus by macrophages exerts cytoprotective effects manifested by the upregulation of antiapoptotic factors. PLoS One 4 e5210

57. McIntyreGF

EricksonAH

1991 Procathepsins L and D are membrane-bound in acidic microsomal vesicles. J Biol Chem 266 15438 15445

58. BeaujouinM

BaghdiguianS

Glondu-LassisM

BerchemG

Liaudet-CoopmanE

2006 Overexpression of both catalytically active and -inactive cathepsin D by cancer cells enhances apoptosis-dependent chemo-sensitivity. Oncogene 25 1967 1973

59. CaponyF

MorissetM

BarrettAJ

CaponyJP

BroquetP

1987 Phosphorylation, glycosylation, and proteolytic activity of the 52-kD estrogen-induced protein secreted by MCF7 cells. J Cell Biol 104 253 262

60. NylandstedJ

Gyrd-HansenM

DanielewiczA

FehrenbacherN

LademannU

2004 Heat shock protein 70 promotes cell survival by inhibiting lysosomal membrane permeabilization. J Exp Med 200 425 435

61. KeaneJ

Balcewicz-SablinskaMK

RemoldHG

ChuppGL

MeekBB

1997 Infection by Mycobacterium tuberculosis promotes human alveolar macrophage apoptosis. Infect Immun 65 298 304

62. HortonRM

HuntHD

HoSN

PullenJK

PeaseLR

1989 Engineering hybrid genes without the use of restriction enzymes: gene splicing by overlap extension. Gene 77 61 68

63. IbrahimYM

KerrAR

McCluskeyJ

MitchellTJ

2004 Control of virulence by the two-component system CiaR/H is mediated via HtrA, a major virulence factor of Streptococcus pneumoniae. J Bacteriol 186 5258 5266

64. FreeP

HurleyCA

KageyamaT

ChainBM

TaborAB

2006 Mannose-pepstatin conjugates as targeted inhibitors of antigen processing. Org Biomol Chem 4 1817 1830

65. MarriottHM

HellewellPG

CrossSS

IncePG

WhyteMK

2006 Decreased alveolar macrophage apoptosis is associated with increased pulmonary inflammation in a murine model of pneumococcal pneumonia. J Immunol 177 6480 6488

66. LuhrmannA

HaasA

2000 A method to purify bacteria-containing phagosomes from infected macrophages. Methods Cell Sci 22 329 341