#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#
preLekára.sk / Odborné časopisy / PLOS Pathogens / 2019 - 10

Correction: A specific sequence in the genome of respiratory syncytial virus regulates the generation of copy-back defective viral genomes

Authors: Yan Sun;  Eun Ji Kim;  Sébastien A. Felt;  Louis J. Taylor;  Divyansh Agarwal;  Gregory R. Grant;  Carolina B. López
Published in the journal: Correction: A specific sequence in the genome of respiratory syncytial virus regulates the generation of copy-back defective viral genomes. PLoS Pathog 15(10): e1008099. doi:10.1371/journal.ppat.1008099
Category: Correction
doi: https://doi.org/10.1371/journal.ppat.1008099

There is an error in the accession number for the RSV isolate used in Fig 6, “A conserved rejoin region determines cbDVG formation in infected human patients”, as well as in its caption. Please see the correct Fig 6 and the complete, correct Fig 6 caption here.

Fig. 1. A conserved rejoin region determines cbDVG formation in infected human patients.
A conserved rejoin region determines cbDVG formation in infected human patients.
(A) Four specimens from RSV A-positive pediatric patients with low content of DVGs and 6 with high content of DVGs were selected for RNA-seq. All seq reads that passed the quality threshold were analyzed by VODKA to screen for cbDVG junctions. DVG junction reads were then aligned to the RSV reference genome NCBI KJ672447. Blue histogram shows a synopsis of total coverage at any given position of the RSV reference genome (illustrated by the y-axis). The number on the right side of the graph represents the total reads at the position with highest coverage. (B) AU-content (top, purple) within nucleotides 14700–15109 of the RSV strain A isolate KJ672447 (human samples) is plotted centered on a 40 base-pair sliding window in both plots. Grey box indicated the position of Rejoin1 and Trailer. Individual rejoin points identified by DVG junction reads from pediatric samples within this region are represented by red ticks underneath the graph. The rejoin points from in vitro infection of RSV stocks 1–6 are plotted using blue ticks. The darker color represented increased rejoin frequency at a given position. (C) Top 6 major DVGs identified from clinical samples are depicted by dashed lines that join their break points (red arrows) and rejoin points (black arrows). The thickness of the line represents the frequency of DVG reads at a given DVG as indicated. The number of patients that have the particular DVG is indicated at the right of the rejoin point for each cbDVG.
Zdroje

1. Sun Y, Kim EJ, Felt SA, Taylor LJ, Agarwal D, Grant GR, et al. (2019) A specific sequence in the genome of respiratory syncytial virus regulates the generation of copy-back defective viral genomes. PLoS Pathog 15(4): e1007707. https://doi.org/10.1371/journal.ppat.1007707 30995283

Štítky
Hygiena a epidemiológia Infekčné lekárstvo Laboratórium
Článek Type I interferon-dependent CCL4 is induced by a cGAS/STING pathway that bypasses viral inhibition and protects infected tissue, independent of viral burden
Článek A comparative epigenome analysis of gammaherpesviruses suggests cis-acting sequence features as critical mediators of rapid polycomb recruitment
Článek The ROP16III-dependent early immune response determines the subacute CNS immune response and type III Toxoplasma gondii survival
Článek Cooperativity between the 3’ untranslated region microRNA binding sites is critical for the virulence of eastern equine encephalitis virus
Článek Oxamniquine resistance alleles are widespread in Old World Schistosoma mansoni and predate drug deployment
Článek Diet–microbiome–disease: Investigating diet’s influence on infectious disease resistance through alteration of the gut microbiome
Článek Stable integrant-specific differences in bimodal HIV-1 expression patterns revealed by high-throughput analysis
Článek Analysis of a fully infectious bio-orthogonally modified human virus reveals novel features of virus cell entry
Článek Does rotavirus turn on type 1 diabetes?
Článek Respiratory syncytial virus nonstructural proteins 1 and 2: Exceptional disrupters of innate immune responses
Článek Shiga toxin sub-type 2a increases the efficiency of Escherichia coli O157 transmission between animals and restricts epithelial regeneration in bovine enteroids
Článek Parasite microbiome project: Grand challenges
Článek Phage resistance at the cost of virulence: Listeria monocytogenes serovar 4b requires galactosylated teichoic acids for InlB-mediated invasion
Článek Influenza virus polymerase subunits co-evolve to ensure proper levels of dimerization of the heterotrimer
Článek Twenty years of West Nile virus spread and evolution in the Americas visualized by Nextstrain
Článek Plasmodium kinesin-8X associates with mitotic spindles and is essential for oocyst development during parasite proliferation and transmission
Článek Astrovirus replication in human intestinal enteroids reveals multi-cellular tropism and an intricate host innate immune landscape
Článek USP18 is a significant driver of memory CD4 T-cell reduced viability caused by type I IFN signaling during primary HIV-1 infection
Článek Induction of PGRN by influenza virus inhibits the antiviral immune responses through downregulation of type I interferons signaling
Článek Ebola virus-mediated T-lymphocyte depletion is the result of an abortive infection
Článek Alterations in cellular expression in EBV infected epithelial cell lines and tumors
Článek Lung transcriptional unresponsiveness and loss of early influenza virus control in infected neonates is prevented by intranasal Lactobacillus rhamnosus GG
Článek Effector memory differentiation increases detection of replication-competent HIV-l in resting CD4+ T cells from virally suppressed individuals
Článek Fosmidomycin, an inhibitor of isoprenoid synthesis, induces persistence in Chlamydia by inhibiting peptidoglycan assembly
Článek P200 family protein IFI204 negatively regulates type I interferon responses by targeting IRF7 in nucleus
Článek Infectious vaccine-derived rubella viruses emerge, persist, and evolve in cutaneous granulomas of children with primary immunodeficiencies
Článek Fingolimod retains cytolytic T cells and limits T follicular helper cell infection in lymphoid sites of SIV persistence
Článek Independent effects on cellular and humoral immune responses underlie genotype-by-genotype interactions between Drosophila and parasitoids
Článek Nedd8 hydrolysis by UCH proteases in Plasmodium parasites
Článek Correction: Immune-inducible non-coding RNA molecule lincRNA-IBIN connects immunity and metabolism in Drosophila melanogaster
Článek Co-opting the fermentation pathway for tombusvirus replication: Compartmentalization of cellular metabolic pathways for rapid ATP generation
Článek The interferon stimulated gene 20 protein (ISG20) is an innate defense antiviral factor that discriminates self versus non-self translation
Článek Cell autonomous and non-autonomous functions of plant intracellular immune receptors in stomatal defense and apoplastic defense
Článek The herpes simplex virus host shutoff (vhs) RNase limits accumulation of double stranded RNA in infected cells: Evidence for accelerated decay of duplex RNA
Článek Development of a new largely scalable in vitro prion propagation method for the production of infectious recombinant prions for high resolution structural studies
Článek A three-dimensional RNA motif mediates directional trafficking of Potato spindle tuber viroid from epidermal to palisade mesophyll cells in Nicotiana benthamiana
Článok vyšiel v časopise

PLOS Pathogens

2019 Číslo 10
Najčítanejšie tento týždeň
Najčítanejšie v tomto čísle
Kurzy

Zvýšte si kvalifikáciu online z pohodlia domova

Aktuální možnosti diagnostiky a léčby litiáz
nový kurz
Autori: MUDr. Tomáš Ürge, PhD.
Všetky kurzy
Prihlásenie
Zabudnuté heslo

Zadajte e-mailovú adresu, s ktorou ste vytvárali účet. Budú Vám na ňu zasielané informácie k nastaveniu nového hesla.

Prihlásenie

Nemáte účet?  Registrujte sa

#ADS_BOTTOM_SCRIPTS#