Distinct rates and patterns of spread of the major HIV-1 subtypes in Central and East Africa

English version

Autoři: Nuno R. Faria ^aff001; Nicole Vidal ^aff002; José Lourenco ^aff001; Jayna Raghwani ^aff001; Kim C. E. Sigaloff ^aff003; Andy J. Tatem ^aff005; David A. M. van de Vijver ^aff007; Andrea-Clemencia Pineda-Peña ^aff008; Rebecca Rose ^aff010; Carole L. Wallis ^aff011; Steve Ahuka-Mundeke ^aff012; Jean-Jacques Muyembe-Tamfum ^aff012; Jérémie Muwonga ^aff013; Marc A. Suchard ^aff014; Tobias F. Rinke de Wit ^aff003; Raph L. Hamers ^aff003; Nicaise Ndembi ^aff015; Guy Baele ^aff016; Martine Peeters ^aff002; Oliver G. Pybus ^aff001; Philippe Lemey ^aff016; Simon Dellicour ^aff016
Působiště autorů: Department of Zoology, University of Oxford, Oxford, United Kingdom ^aff001; TransVIHMI, Institut de Recherche pour le Développement, INSERM, and University of Montpellier, Montpellier, France ^aff002; Amsterdam Institute for Global Health and Development, Department of Global Health, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands ^aff003; Department of Internal Medicine, Section of Infectious Diseases, VU University Medical Center, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands ^aff004; Department of Geography and Environment, University of Southampton, Southampton, United Kingdom ^aff005; Flowminder Foundation, Stockholm, Sweden ^aff006; Viroscience Department, Erasmus Medical Center, Rotterdam, The Netherlands ^aff007; Global Health and Tropical Medicine—Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Lisboa, Portugal ^aff008; Molecular Biology and Immunology Department, Fundación Instituto de Inmunología de Colombia, Basic Sciences Department, Universidad del Rosario, Bogotá, Colombia ^aff009; Bioinfoexperts, LLC, Thibodaux, Los Angeles, United States of America ^aff010; Department of Molecular Pathology, Lancet Laboratories and BARC-SA, Johannesburg, South Africa ^aff011; Institut National de Recherche Biomedicales, Kinshasa, Democratic Republic of Congo and Service de Microbiologie, Cliniques Universitaires de Kinshasa, Kinshasa, Democratic Republic of Congo ^aff012; AIDS national laboratory and Service de Microbiologie, Cliniques Universitaires de Kinshasa, Kinshasa, Democratic Republic of Congo ^aff013; Departments of Biomathematics and Human Genetics David Geffen School of Medicine at UCLA, and Department of Biostatistics UCLA School of Public Health, Los Angeles, United States of America ^aff014; Institute of Human Virology, Abuja, Nigeria ^aff015; KU Leuven, Department of Microbiology and Immunology, Rega Institute, Laboratory for Clinical and Epidemiological Virology, Leuven, Belgium ^aff016; Spatial Epidemiology Lab, Université Libre de Bruxelles, Bruxels, Belgium ^aff017
Vyšlo v časopise: Distinct rates and patterns of spread of the major HIV-1 subtypes in Central and East Africa. PLoS Pathog 15(12): e32767. doi:10.1371/journal.ppat.1007976
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.ppat.1007976

Souhrn

Since the ignition of the HIV-1 group M pandemic in the beginning of the 20th century, group M lineages have spread heterogeneously throughout the world. Subtype C spread rapidly through sub-Saharan Africa and is currently the dominant HIV lineage worldwide. Yet the epidemiological and evolutionary circumstances that contributed to its epidemiological expansion remain poorly understood. Here, we analyse 346 novel pol sequences from the DRC to compare the evolutionary dynamics of the main HIV-1 lineages, subtypes A1, C and D. Our results place the origins of subtype C in the 1950s in Mbuji-Mayi, the mining city of southern DRC, while subtypes A1 and D emerged in the capital city of Kinshasa, and subtypes H and J in the less accessible port city of Matadi. Following a 15-year period of local transmission in southern DRC, we find that subtype C spread at least three-fold faster than other subtypes circulating in Central and East Africa. In conclusion, our results shed light on the origins of HIV-1 main lineages and suggest that socio-historical rather than evolutionary factors may have determined the epidemiological fate of subtype C in sub-Saharan Africa.

Klíčová slova:

Sequence analysis – Phylogenetics – Phylogenetic analysis – Africa – HIV-1 – Phylogeography – Uganda – HIV epidemiology

Zdroje

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