Place of inhibin B investigation in clinical andrological praxis

Česká verzia

Authors: I. Poršová-Dutoit
Authors place of work: Šilinkův nadační fond Praha, vedoucí prof. MUDr. RNDr. Luboslav Stárka, DrSc.
Published in the journal: Vnitř Lék 2008; 54(11): 1059-1062
Category: Přehledný referát

Summary

Inhibin B is a gonadal dimeric peptide, produced in men in testicular Sertolli cells. Inhibin B blood level knowledge can be a useful tool in the management of difficult diagnostic problems, such as ambiguous genitalia, the distinction between cryptorchidism and anorchidism and the hypogonadotrophic hypogonadism/delayed puberty differential diagnosis. Inhibin B measurements can help in gonadal dysgenesis evaluation, androgen insensitivity management and also in the diagnosis of some gonadal tumors. In adult men, inhibin B evaluation is helpful in the investigation of male infertility, especially in the judgment of the pro-gnosis of testicular biopsy in in‑vitro fertilization programs. Although commercial kits for inhibin B measurement are available at present, its evaluation is accessible in the Czech Republic for the time being in only very limited number of laboratory centers.

Key words:
inhibin – ambiguous genitalia – cryptorchidism – puberty – gonadal tumors – infertility

Zdroje

1. Adan L, Couto-Silva AC, Trivin C et al. Congenital gonadotropin deficiency in boys: management during childhood. J Pe-diatr Endocrinol Metab 2004; 17: 149–155.

2. Andersson AM, Toppari J, Haavisto AM et al. Longitudinal reproductive hormone profiles in infants: peak of inhibin B levels in infant boys exceeds levels in adult men. J Clin Endocrinol Metab 1998; 83: 675–661.

3. Arrigo T, Pirazzoli P, De Sanctis L et al. McCune-Albright syndrome in a boy may present with a monolateral macroorchidism as an early and isolated clinical manifestation. Horm Res 2006; 65: 114–119.

4. Babčová K, Ulčová-Gallová Z, Červenková Z et al. Inhibin B and intraacrosomal proteins in men from the couples with fertility disorders. Čes Gynekol 2006; 71: 111–117.

5. Bauer J, Blumenthal S, Reuber M et al. Epilepsy syndrome, focus location, and treatment choice affect testicular function in men with epilepsy. Neurology 2004; 62: 243–246.

6. Bohring C, Schroeder-Printzen I, Weidner W et al. Serum levels of inhibin B and follicle-stimulating hormone may predict successful sperm retrieval in men with azoo-spermia who are undergoing testicular sperm extraction. Fertil Steril 2002; 78: 1195–1198.

7. Bouvattier C, Carel JC, Lecointre C et al. Postnatal changes of T, LH, and FSH in 46,XY infants with mutations in the AR gene. J Clin Endocrinol Metab 2002; 87: 29–32.

8. Cortes D, Thorup J, Hogdall E et al. The relation of germ cells per tubule in testes, serum inhibin B and FSH in cryptorchid boys. Pediatr Surg Int 2007; 23: 163–169.

9. Coutant R, Lumbroso S, Rey R et al. Macroorchidism due to autonomous hyperfunction of Sertoli cells and G(s)alpha gene mutation: an unusual expression of McCune-Albright syndrome in a prepubertal boy. J Clin Endocrinol Metab 2001; 86: 1778–1781.

10. Červenková Z, Ulčová-Gallová Z, Babcová K et al. Present knowledge on inhibins B and A. Čes gynekol 2006; 71: 79–82.

11. Gray PC, Greenwald J, Blount AL et al. Identification of a binding site on the type II activin receptor for activin and inhibin. J Biol Chem 2000; 275: 3206–3212.

12. Groome NP, Tsigou A, Cranfield M et al. Enzyme immunossays for inhibins, activins and follistations. Mol Cell Endocrinol 2001; 180: 73–77.

13. Hemminki A, Markie D, Tomlinson I et al. A serine/threonine kinase gene defective in Peutz-Jeghers syndrome. Nature 1998; 391: 184–187.

14. Hurwitz JM, Santoro N. Inhibins, activins, and follistatin in the aging female and male. Semin Reprod Med 2004; 22: 209–217.

15. Chada M, Průša R, Bronský J et al. Inhibin B, follicle stimulating hormone, luteinizing hormone and testosterone during childhood and puberty in males: changes in serum concentrations inrelation to age and stage of puberty. Physiol Res 2003; 52: 45–51.

16. Christiansen P, Andersson AM, Skakkebaek NE et al. Serum inhibin B, FSH, LH and testosterone levels before and after human chronic gonadotropin stimulation in prepubertal boys with cryptorchidism. Eur J Endocrinol 2002; 147: 95–101.

17. Christiansen P, Andersson AM, Skakkebaek NE. Longitudinal studies of inhibin B levels in boys and young adults with Klinefelter syndrome. J Clin Endocrinol Metab 2003; 88: 888–891.

18. Iczkowski KA, Bostwick DG, Roche PC et al. Inhibin A is a sensitive and specific marker for testicular sex cord-stromal tumors. Mod Pathol 1998; 11: 774–779.

19. Illingworth PJ, Groome NP, Byrd W et al. Inhibin‑B: a likely candidate for the physiologically important form of inhibin in men. J Clin Endocrinol Metab 1996; 81: 1321–1325.

20. Kubini K, Zachmann M, Albers N et al. Basal inhibin B and the testosterone response to human chorionic gonadotropin correlate in prepubertal boys. J Clin Endocrinol Metab 2000; 85: 134–138.

21. Lahlou N, Fennoy I, Carel JC et al. Inhibin B and anti‑Müllerian hormone, but not testosterone levels, are normal in infants with nonmosaic Klinefelter syndrome. J Clin Endocrinol Metab 2004; 894: 1864–1868.

22. Lahlou N, Roger M. Inhibin B in pubertal development and pubertal disorders. Semin Reprod Med 2004; 22: 165–176.

23. Lefevre H, Bouvattier C, Lahlou N et al. Prepubertal gynecomastia in Peutz-Jeghers syndrome: incomplete penetrance in a familial case and management with an aromatase inhibitor. Eur J Endocrinol 2006; 154: 221–227.

24. Lockwood G. The diagnostic value of inhibin in infertility evaluation. Semin Reprod Med 2004; 22: 195–208.

25. Meachem SJ, Nieschlag E, Simoni M. Inhibin B in male reproduction: pathophysiology and clinical relevance. Eur J Endocrinol 2001; 145: 561–571.

26. Meikle AW. The interrelationships between thyroid dysfunction and hypogonadism in men and boys. Thyroid 2004; 14 (Suppl 1): S17–S25.

27. McCullagh DR. Dual endocrine activity of the testes. Science 1932; 76: 19–20.

28. Misra M, MacLaughlin DT, Donahoe PK et al. Measurement of Mullerian inhibiting substance facilitates management of boys with microphallus and cryptorchidism. J Clin Endocrinol Metab 2002; 87: 3598–3602.

29. O’Connor AE, de Kretser DM. Inhibins in normal male physiology. Semin Reprod Med 2004; 22: 177–185.

30. Pauli EM, Legro RS, Demers LM et al. Diminished paternity and gonadal function with increasing obesity in men. Fertil Steril 2008; Epub Feb 19.

31. Pierik FH, Abdesselam SA, Vreeburg JT et al. Increased serum inhibin B levels after varicocele treatment. Clin Endocrinol (Oxf) 2001; 54: 775–780.

32. Pigny P, Dewailly D, Racadot A et al. Famille des inhibines et des activines: de I’action endocrine à I’action paracrine. Ann Endocrinol (Paris) 1996; 57: 385–394.

33. Pitteloud N, Hayes FJ, Boepple PA et al. The role of prior pubertal development, biochemical markers of testicular maturation, and genetics in elucidating the phenotypic heterogeneity of idiopathic hypogonadotropic hypogonadism. J Clin Endocrinol Metab 2002; 87: 152–160.

34. Poršová-Dutoit I. Male hormonal con--traception. Vnitř Lék 2006; 52: 1077–1084.

35. Rajpert-De Meyts E, Jørgensen N, Graem N et al. Expression of anti‑Müllerian hormone during normal and pathological gonadal development: association with differentiation of Sertoli and granulosa cells. J Clin Endocrinol Metab 1999; 84: 3836–3844.

36. Rey R. How to evaluate gonadal function in the cryptorchid boy. Lessons from new testicular markers. J Pediatr Endocrinol Metab 2003; 16: 357–364.

37. Rey R, Mebarki F, Forest MG et al. Anti‑müllerian hormone in children with androgen insensitivity. J Clin Endocrinol Metab 1994; 79: 960–964.

38. Risbridger GP, Schmitt JF, Robertson DM. Activins and inhibins in endocrine and other tumors. Endocr Rev 2001; 22: 836–858.

39. Schmiegelow M, Lassen S, Poulsen HS et al. Gonadal status in male survivors following childhood brain tumors. J Clin Endocrinol Metab 2001; 86: 2446–2452.

40. Schneyer A. Inhibins: a historical perspective. Semin Reprod Med 2004; 22: 161–164.

41. Shenker A, Laue L, Kosugi S et al. A constitutively activating mutation of the luteinizing hormone receptor in familial male precocious puberty. Nature 1993; 365: 652–654.

42. Soriano-Guillen L, Mitchell V, Carel JC et al. Activating mutations in the LH receptor gene: a human model of non FSH-dependent inhibin production and germ cell maturation. J Clin Endocrinol Metab 2006; 91: 3041–3047.

43. Vale W, Rivier C, Hsueh A et al. Chemical and biological characterization of the inhibins family of protein hormones. Recent Prog Horm Res 1988; 44: 1–34.

44. Ying SY. Inhibins, activins, and follistatins: gonadal proteins modulating the secretion of follicle-stimulating hormone. Endocr Rev 1988; 9: 267–293.

45. Young J, Couzinet B, Chanson P et al. Effects of human recombinant luteinizing hormone and follicle-stimulating hormone in patients with acquired hypogonadotropic hypogonadism: study of Sertoli and Leydig cell secretions and interactions. J Clin Endocrinol Metab 2000; 85: 3239–3244.

46. Young J, Chanson P, Salenave S et al. Testicular anti‑mullerian hormone secretion is stimulated by recombinant human FSH in patients with congenital hypogonadotropic hypogonadism. J Clin Endocrinol Metab 2005; 90: 724–728.

47. Žofková I, Bubeníček P, Sotorník I. Hypogonadism, a serious complication of chronic renal insufficiency. Vnitř Lék 2007; 53: 709–14.