Could we soon have the final evidence of cardiovascular safety of DPP-4 inhibitors?

Česká verzia

Authors: Žák P.
Authors place of work: II. interní klinika LF MU a FN U sv. Anny v Brně
Published in the journal: Kardiol Rev Int Med 2019, 21(1): 33-36

Summary

Heart failure is a common complication in patients with DM2, and is associated with poor long-term prognosis. Understanding the potential adverse effects of antidiabetic drugs is critical. The SAVOR-TIMI 53 trial with DPP-4 inhibitor saxagliptin in patients at high cardiovascular risk showed an increased risk of heart failure (HF) requiring hospitalization. Approximately 50% of patients with DM2 have proven diabetic kidney disease, which is associated with a significant increase of the risk of progression to end-stage kidney disease and an increased risk of premature death. The CARMELINA study with DPP-4 inhibitor linagliptin proved non-inferiority for the primary outcome (the time to the first occurrence of CV death, non-fatal myocardial infarction, or non-fatal stroke). CARMELINA was also designed to evaluate renal outcomes of linagliptin treatment; there was no significant difference between linagliptin and placebo for composite renal outcome. In June this year we should receive the results of a further study with CV objectives, CAROLINA, where linagliptin treatment is compared with the active component sulphonylurea (glimepiride). We should soon receive a full image of cardiovascular safety of treatment with DPP-4 inhibitors.

Keywords:

heart failure – cardiovascular risk – kidney disease – DPP-4 inhibitors

Zdroje

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