Novel approaches in the pharmacotherapy of heart failure with preserved ejection fraction
Authors:
Andreasová T.; Málek F.
Authors place of work:
Nemocnice Na Homolce, Praha
Published in the journal:
Kardiol Rev Int Med 2020, 22(1): 29-32
Summary
Heart failure with preserved ejection fraction (EF) is common in the population of subjects with this clinical syndrome and treatment is difficult. Disease-modifying drugs in heart failure with reduced EF have not been effective in subjects with preserved EF. Treatment of ischaemic heart disease, arterial hypertension and rhythm and rate control in atrial fibrillation are the recommended therapeutic approaches in this patient population. Dual inhibition of the renin-angiotensin system at the level of the angiotensin II receptor together with neprilysin inhibitor looked promising. The results of the randomised study of sacubitril/valsartan in patients with heart failure and preserved left ventricular EF were not uniquely favourable. There are new drugs in clinical research and their mechanism of action is completely different.
Keywords:
new drugs – pharmacotherapy – heart failure – preserved ejection fraction
Zdroje
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Štítky
Paediatric cardiology Internal medicine Cardiac surgery CardiologyČlánok vyšiel v časopise
Cardiology Review
2020 Číslo 1
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