Paraneoplastic Neurological Syndrome in 64-year-old Patient in Association with a Small Cell Lung Carcinoma

Česká verzia

Authors: Z. Prouzová; S. Brychtová
Authors place of work: Ústav klinické a molekulární patologie LF UP a FN Olomouc
Published in the journal: Klin Onkol 2012; 25(6): 471-475
Category: Case Reports

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Obdrženo: 26. 6. 2012
Přijato: 3. 8. 2012

Summary

Background:
Paraneoplastic neurological syndromes are rare conditions manifest as psychiatric/neurological symptoms. They are caused by autoimmunne cross-reaction leading to destruction of the central nervous system.

Case:
We present the case of a 64-year-old patient hospitalized for 6 months at the Department of Psychiatry for persisting depression. During that time he progressed to delirium. A diagnosis of diffuse encephalopathy was made, but further examination revealed a small cell lung cancer with generalisation. A paraneoplastic syndrome was finally diagnosed after autoptic and histologic examination.

Conclusion:
Paraneoplastic neurological syndomes can be early signs of malignancy and may considerably precede oncologic diagnosis.

Key words:
paraneoplastic syndromes – Hu antigens – small cell lung carcinoma – cross reactions – paraneoplastic eucephalomyelitis

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