Preinvasive Lesions in Gynaecology – Ovary

Česká verzia

Authors: R. Feranec; L. Mouková
Authors place of work: Oddělení gynekologické onkologie, Masarykův onkologický ústav, Brno
Published in the journal: Klin Onkol 2013; 26(Supplementum): 54-55

Summary

In comparison to malignant tumors of vulva, vagina, cervix and uterine corpus, clear morphologic and molecular genetic features of precursor lesions of ovarian carcinoma have not been defined yet. We can see an effort to describe preinvasive lesions to allow diagnostics and treatment prior to development of invasive ovarian cancer. This tendency is magnified by the fact that ovarian carcinomas have the highest mortality from all gynecological malignancies. Currently, reports confirming different morphology, pathogenesis and molecular alterations in heterogeneous group of ovarian carcinomas have been described. There is a tendency to divide epithelial malignant tumors into two groups. Low‑ grade ovarian serous carcinoma, low‑ grade endometrioid, clear‑ cell, mucinous ovarian cancers and Brenner tumors of ovary are categorized as type I ovarian tumors. High‑grade serous carcinoma, undifferentiated carcinomas and malignant mixed mesodermal tumors of the ovary (MMMTs) belong to type II tumors. A potential precursor lesion of high‑grade serous ovarian cancer has been defined – serous tubal intraepithelial carcinoma.

Key words:
preinvasive lesion – ovarian cancer – serous tubal intraepithelial carcinoma (STIC)

The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manuscript met the ICMJE “uniform requirements” for biomedical papers.

Submitted:
11. 9. 2013

Accepted:
9. 10. 2013

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