Premalignant Conditions of the Small Bowel

Česká verzia

Authors: P. Drastich
Authors place of work: Klinika hepatogastroenterologie, IKEM, Praha
Published in the journal: Klin Onkol 2013; 26(Supplementum): 34-37

Summary

Small intestinal dysplastic lesions are rare and difficult to detect before they progress to cancer. New investigative modalities, such as capsule endoscopy and double‑balloon enteroscopy, are very promising in search for premalignant lesions. Screening patients at high-risk for small bowel neoplasia is the only sensible approach. Duodenal adenoma represents the most easily accessible tumors with the possibility of curative endoscopic resection. Due to the strong association of the small bowel and colonic adenomas, it is always necessary to perform colonoscopy. In young patients, the exclusion of familial polyposis by genetic testing is always mandatory. Patients with celiac disease are especially at risk of developing non‑Hodgkin‘s lymphomas and adenocarcinomas. There is a high-risk of ampuloma and other adenomas in patients with familial adenomatous polyposis. Patients with prolonged and complicated course of Crohn‘s disease, Peutz‑ Jegher’s syndrome and patients with ileoanal pouch have higher risk of adenocarcinoma of the small intestine.

Key words:
small bowel adenoma – celiac disease – Peutz‑ Jeghers syndrome – familial adenomatous polyposis – non‑Hodgkin’s lymphoma

The author declare he has no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manuscript met the ICMJE “uniform requirements” for biomedical papers.

Submitted:
10. 9. 2013

Accepted:
27. 9. 2013

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