Influence of Preoperative Chemoradiotherapy on Changes of Epidermal Growth Factor Receptor Expression in Patients Treated by Preoperative Chemoradiotherapy for Local Advanced Rectal Carcinoma
Authors:
I. Richter 1; J. Dvořák 2
; A. Blüml 3; Eva Čermáková 4
; J. Bartoš 1; M. Urbanec 5; V. Sitorová 6; A. Ryška 6; I. Sirák 7; D. Buka 7; A. Ferko 8; B. Melichar 9; J. Petera 7
Authors place of work:
Onkologické oddělení, Krajská nemocnice Liberec, a. s.
1; Onkologická klinika 1. LF UK a Thomayerova nemocnice, Praha
2; Oddělení patologie, Krajská nemocnice Liberec, a. s.
3; Ústav biofyziky a informatiky, LF UK v Hradci Králové
4; Oddělení patologie, Nemocnice s poliklinikou Česká Lípa, a. s.
5; Fingerlandův patologický ústav, LF UK v Hradci Králové
6; Klinika onkologie a radioterapie LF UK a FN Hradec Králové
7; Chirurgická klinika LF UK a FN Hradec Králové
8; Onkologická klinika LF UP a FN Olomouc
9
Published in the journal:
Klin Onkol 2014; 27(5): 361-366
Category:
Original Articles
doi:
https://doi.org/10.14735/amko2014361
Summary
Aim:
The aim of this retrospective study was to determine the prognostic impact of expression of epidermal growth factor receptor (EGFR) changes during neoadjuvant chemoradiotherapy in patients with locally advanced rectal adenocarcinoma.
Material and Methods:
One hundred and three patients with locally advanced rectal adenocarcinoma of stage II and III were evaluated. All patients were administered the total dose of 44– 50.4 Gy. Concomitantly, the patients received capecitabine in the dose 825 mg/ m2 in two daily oral administrations or 5- fluorouracil in the dose 200 mg/ m2 in continuous infusion. Surgery was indicated at intervals of 4– 8 weeks from chemoradiotherapy completion. EGFR expression in the pretreatment biopsies and in resected specimens was assessed with immunohistochemistry.
Results:
All of 103 patients received radiotherapy without interruption up to the total planned dose. Downstaging was described in 64 patients. Six patients had complete pathologic remission. Recurrence occurred in 49 patients. Local recurrence was found in 22 patients, generalization of disease was reported in 27 patients. A total of 51 patients died. Increased EGFR expression was found in 26 patients. The statistically significantly shorter overall survival (p < 0.001) and disease-free survival (p < 0.001) was found in patients with increased expression of EGFR compared with patients where no increase in the expression of EGFR was observed during neoadjuvant chemoradiotherapy.
Conclusions:
The overexpression of EGFR during neoadjuvant chemoradiotherapy for locally advanced rectal adenocarcinoma is associated with significant shorter overall survival and disease-free survival.
Key words:
rectal cancer – neoadjuvant therapy – chemoradiotherapy – monoclonal antibodies – epidermal growth factor receptor
This study was supported by the Scientific Council of the Regional Hospital Liberec, plc VR130304 and by project PRVOUK P37/01.
The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.
The Editorial Board declares that the manuscript met the ICMJE “uniform requirements” for biomedical papers.
Submitted:
12. 8. 2014
Accepted:
26. 8. 2014
Zdroje
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