The Role of MicroRNAs in the Pathophysiology of Neuroblastoma and Their Possible Use in Diagnosis, Prognosis and Therapy

Česká verzia

Authors: J. Vinklárek ¹; J. Novák ^1,2; J. Bienertová-Vašků ^1,3,4; J. Štěrba ³; O. Slabý ⁴
Authors place of work: Ústav patologické fyziologie, LF MU, Brno ¹; Fyziologický ústav, LF MU, Brno ²; Klinika dětské onkologie LF MU a FN Brno ³; Molekulární onkologie II, CEITEC – Středoevropský technologický institut, MU, Brno ⁴
Published in the journal: Klin Onkol 2014; 27(5): 331-339
Category: Reviews
doi: https://doi.org/10.14735/amko2014331

Summary

Neuroblastoma (NBL) is a typical childhood tumor developing from the precursor cells of the sympathetic nervous tissue and accounting for approximately 7% of total malignancies in pediatrics and 15% of deaths associated with this malignancy. MicroRNAs (miRNAs) are small single-stranded RNA molecules that are involved in posttranscriptional regulation of gene expression, whereas the pathophysiology of neuroblastoma tumor growth involves both upregulation of the protooncogenic miRNAs as well as downregulation of the tumor-suppresor ones. Comparison of the expression profiles of miRNAs in specific subtypes of neuroblastoma seems to be a useful tool adding to the classification of the diseases, and the assessment of the levels of specific miRNAs may be useful for estimation of the individual treatment response as well as prognosis of the patient. This paper provides the basic review of the studies focused on the role of miRNAs in pathogenesis of neuroblastoma and provides a survey of current/ possible use of these miRNAs in diagnostics, therapy or prognosis estimation in the neuroblastoma patients.

Key words:
neuroblastoma – microRNA – diagnosis – therapy – prognosis

The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manuscript met the ICMJE “uniform requirements” for biomedical papers.

Submitted:
15. 10. 2013

Accepted:
1. 9. 2014

Zdroje

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