Importance of the Immune System and Immunotherapeutic Options in Malignant Melanoma

Česká verzia

Authors: I. Krajsová
Authors place of work: Dermatovenerologická klinika 1. LF UK a VFN v Praze
Published in the journal: Klin Onkol 2015; 28(Supplementum 4): 56-63
Category: Specials
doi: https://doi.org/10.14735/amko20154S56

Summary

Over the past several years, many important changes in the treatment of metastatic melanoma have occurred. New treatment options have been discovered to exploit inhibition of immune checkpoints for promotion of antitumor immune response. Recent results of clinical studies with anti-CTLA‑ 4 and anti-PD‑ 1 monoclonal antibodies show the ability of immunotherapy to extend progression‑free survival and overall survival in patients with metastatic melanoma when compared to chemotherapy and other therapeutic methods. This article focuses on efficacy and safety of these immunotherapeutic approaches and considered biomarkers of tumor response.

Key words:
malignant melanoma – immunotherapy – ipilimumab – nivolumab – pembrolizumab – combined immunotherapy – biomarkers

I declare that, in connection with the above-mentioned contribution, which I am an author, I have a conflict of interest with the following companies: BMS, MSD, Novartis and Roche (consultations and lectures honorarias).

The Editorial Board declares that the manuscript met the ICMJE recommendation for biomedical papers.

Submitted:
24. 7. 2015

Accepted:
10. 9. 2015

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