Emotional Memory – Pathophysiology and Clinical Associations

Česká verzia

Authors: I. Mokrišová ¹; M. Vališ ²; J. Hort ^1,3
Authors place of work: Kognitivní centrum, Neurologická klinika 2. LF UK a FN v Motole, Praha ¹; Oddělení urgentní medicíny, FN Hradec Králové ²; Mezinárodní centrum klinického výzkumu, FN u sv. Anny v Brně ³
Published in the journal: Cesk Slov Neurol N 2012; 75/108(5): 546-551
Category: Review Article

Summary

The amygdala is the main structure involved in emotional memory. This independent memory system is linked to emotional events and interacts with other brain structures (hippocampus, prefrontal cortex, hypothalamus), affecting final memories. Emotional memory is a non--declarative memory but relates to and cooperates with declarative memory. In some pathological states, characterized by amygdalar atrophy and dysfunction, a variety of changes have been reported, including memory deficits of both systems, behavioral changes and reduced attention span. This results in reduced patient quality of life and a greater burden on caregivers. This applies, for example, to patients with Alzheimer’s disease as they have great difficulty with emotional face recognition.

Key words:
emotional memory – amygdala – memory deficits – Alzheimer‘s disease

Zdroje

1. Milner B. The medial temporal-lobe amnesic syndrome. Psychiatr Clin North Am 2005; 28(3): 599–611.

2. Hort J, Vyhnálek M, Bojar M. Časná stádia demence – možnosti diagnostiky a léčby. Neurol Prax 2005; 6(6): 308–311.

3. Topinková E, Jirák R, Kožený J. Krátká neurokognitivní baterie pro screening demence v klinické praxi: sedmi minutový screeningový test. Interní Med 2002; 8(4): 368–391.

4. Ressner P, Hort J, Rektorová I, Bartoš A, Rusina R, Línek V et al. Doporučené postupy pro diagnostiku Alzheimerovy nemoci a ostatních demencí. Cesk Slov Neurol N 2008; 71/104(4): 494–501.

5. Ahn IS, Kim JH, Kim S, Chung JW, Kim H, Kang HS et al. Impairment of instrumental activities of daily living in patients with mild cognitive impairment. Psychiatry Investig 2009; 6(3): 180–184.

6. Maruta C, Guerreiro M, De Mendonça A, Hort J, Scheltens P. The use of neuropsychological tests across Europe: the need for a consensus in the use of assessment tools for dementia. Eur J Neurol 2011; 18(2): 279–285.

7. Horinek D, Brezova V, Nimsky C, Belsan T, Martinkovic L, Masopust V et al. The MRI volumetry of the posterior fossa and its substructures in trigeminal neuralgia: a validated study. Acta Neurochir (Wien) 2009; 151(6): 669–675.

8. Horinek D, Hort J, Brabec J et al. The amygdala volume is decreased in patients with Alzheimer’s disease. Cesk Slov Neurol N 2005; 68/101: 235–240.

9. Hummelová-Fanfrdlová Z, Rektorová I, Sheardová K, Bartos A, Línek V, Ressner P et al. Česká adaptace Addenbrookského kognitivního testu. Cesk Psychol 2009; 53(4): 376–388.

10. Horinek D, Varjassyova A, Hort J. Magnetic resonance analysis of amygdalar volume in Alzheimer’s disease. Curr Opin Psychiatry 2007; 20(3): 273–277.

11. Horinek D, Petrovicky P, Hort J, Krasensky J, Brabec J, Bojar M et al. Amygdalar volume and psychiatric symptoms in Alzheimer’s disease: an MRI analysis. Acta Neurol Scand 2006; 113(1): 40–45.

12. Langmajer M, Marešová D, Mourek J, Trojan S. Amygdala (morfologie, funkce, klinika). Psychiatrie 2006; 10 (Suppl 2): 32–34.

13. LeDoux J. The amygdala. Curr Biol 2007; 23; 17(20): R868–R874.

14. Cunningham-Bussel AC, Root JC, Butler T, Tuescher O, Pan H, Epstein J et al. Diurnal cortisol amplitude and fronto-limbic activity in response to stressful stimuli. Psychoneuroendocrinology 2009; 34(5): 694–704.

15. Schafe GE, Doyère V, LeDoux JE. Tracking the fear engram: the lateral amygdala is an essential locus of fear memory storage. J Neurosci 2005; 25(43): 10010–10014.

16. Mori E, Ikeda M, Hirono N, Kitagaki H, Imamura T, Shimomura T. Amygdalar volume and emotional memory in Alzheimer’s disease. Am J Psychiatry 1999; 156(2): 216–222.

17. Brabec J, Rulseh A, Hoyt B, Vizek M, Horinek D, Hort J et al. Volumetry of the human amygdala – an anatomical study. Psychiatry Res 2010; 182(1): 67–72.

18. Anderson AK, Phelps EA. Lesions of the human amygdala impair enhanced perception of emotionally salient events. Nature 2001; 411(6835): 305–309.

19. Bechara A, Tranel D, Damasio H, Adolphs R, Rockland C, Damasio AR. Double dissociation of conditioning and declarative knowledge relative to the amygdala and hippocampus in humans. Science 1995; 269(5227): 1115–1118.

20. Sroubek J, Hort J, Komarek V, Langmaier M, Brozek G. Acquisition and retrieval of conditioned taste aversion is impaired by brain camage caused by two hours of pilocarpine-induced status epilepticus. Physiol Res 2001; 50(6): 609–617.

21. LaBar K, Phelps EA. Role of the human amygdala in arousal mediated memory consolidation. Psychol Sci 1998; 9(6): 490–493.

22. Levinoff EJ, Saumier D, Chertkow H. Focused attention deficits in patients with Alzheimer’s disease and mild cognitive impairment. Brain Cogn 2005; 57(2): 127–130.

23. Ohman A, Flykt A, Esteves F. Emotion drives attention: detecting the snake in the grass. J Exp Psychol Gen 2001; 130(3): 466–478.

24. Fox E, Russo R, Bowles R, Dotton K. Do threatening stimuli draw or hold visual attention in subclinical anxiety? J Exp Psychol Gen 2001; 130(4): 681–700.

25. Phelps EA. Human emotion and memory: interactions of the amygdala and hippocampal complex. Curr Opin Neurobiol 2004; 14(2): 198–202.

26. Whalen PJ, Rauch SL, Etcoff NL, McInerney SC, Lee MB, Jenike MA. Masked presentations of emotional facial expressions modulate amygdala activity without explicit knowledge. J Neurosci 1998; 18(1): 411–418.

27. Brown ES. Effects of glucocorticoids on mood, memory, and the hippocampus. Treatment and preventive therapy. Ann N Y Acad Sci 2009; 1179: 41–55.

28. Wolkowitz OM, Burke H, Epel ES, Reus VI. Glucocorticoids. Mood, memory, and mechanisms. Ann N Y Acad Sci 2009; 1179: 19–40.

29. McGaugh JL. Memory – a century of consolidation. Science 2000; 287(5451): 248–251.

30. McGaugh JL, Roozendaal B. Role of adrenal stress hormones in forming lasting memories in the brain. Curr Opin Neurobiol 2002; 12(2): 205–210.

31. Cahill L, Babinsky R, Markowitsch HJ, McGaugh JL. The amygdala and emotional memory. Science 1995; 377(6547): 295–296.

32. Gilebus G, Lippa CF. The influence of beta-blockers on delayed memory function in people with cognitive impairment. Am J Alzheimers Dis Other Demen 2007; 22(1): 57–61.

33. Cahill L, Gorski L, Le K. Enhanced human memory consolidation with post-learning stress: interaction with the degree of arousal at encoding. Learn Mem 2003; 10(4): 270–274.

34. Cahill I, Haier RJ, White NS, Fallon J, Kilpatrick L, Lawrence C et al. Sex-related difference in amygdala activity during emotionally influenced memory storage. Neurobiol Learn Mem 2001; 75(1): 1–9.

35. Canli T, Desmond JE, Zhao Z, Gabrieli JD. Sex differences in the neural basis of emotional memories. Proc Natl Acad Sci U S A 2002; 99(16): 10789–10794.

36. Funayama ES, Grillon C, Davis M, Phelps EA. A double dissociation in the affective modulation of startle in humans: effects of unilateral temporal lobectomy. J Cogn Neurosci 2001; 13(6): 721–729.

37. Phelps EA, O’Connor KJ, Gatenby JC, Grillon C, Gore JC, Davis M. Activation of the left amygdala to a cognitive representation of fear. Nat Neurosci 2001; 4(4): 437–441.

38. Ochsner KN, Bunge SA, Gross JJ, Gabrieli JD. Rethinking feelings: an FMRI study of the cognitive regulation of emotion. J Cogn Neurosci 2002; 14(8): 1215–1229.

39. Hanyu H, Asano T, Kogure D, Sakurai H, Iwamoto T, Takasaki M. Relation between hippocampal demage and cerebral cortical fiction in Alzheimer’s disease. Nippon Ronen Igakkai Zasshi 2000; 37(11): 921–927.

40. Schaefer SM, Jackson DC, Davidson RJ, Aquirre GK, Kimberg DY, Thompson-Schill SL. Modulation of amygdalar activity by the conscious regulation of negative emotion. J Cogn Neurosci 2002; 14(6): 913–921.

41. Lopez OL, Becker JT, Sweet RA, Klunk W, Kaufer DI, Saxton J et al. Psychiatric symptoms vary with the severity of dementia in probable Alzheimer’s disease. J Neuropsychiatry Clin Neurosci 2003; 15(3): 346–353.

42. Robert PH, Verhey FR, Byrne EJ, Hurt C, De Deyn PP, Nobili F et al. Grouping for behavioral and psychological symptoms in dementia: clinical and biological aspects. Consensus paper of the European Alzheimer disease consortium. Eur Psychiatry 2005; 20(7): 490–496.

43. Shimabukuro J, Awata S, Matsuoka H. Behavioral and psychological symptoms of dementia characteristic of mild Alzheimer patients. Psychiatry Clin Neurosci 2005; 59(3): 274–279.

44. Rosen HJ, Gorno-Tempini ML, Goldman WP, Perry RJ, Schuff N, Weiner M et al. Patterns of brain atrophy in frontotemporal dementia and semantic dementia. Neurology 2002; 58(2): 198–208.

45. Cummings JL. Toward a molecular neuropsychiatry of neurodegenerative diseases. Ann Neurol 2003; 54(2): 147–154.

46. Lopez OL, Gonzales MP, Becker JT, Reynolds CF, Sudilovsky A, Dekosky ST. Symptoms of depression and psychosis in Alzheimer’s disease and frontotemporal dementia: Exploration of underlying mechanisms. Cogn Behav Neurol 1996; 9(3): 154–161.

47. Finkel SI. Behavioral and psychologic symptoms of dementia. Clin Geriatr Med 2003; 19(4): 799–824.