Toxic Effects of Pesticides

Česká verzia

Authors: J. Žďárová Karasová
Authors place of work: Centrum biomedicínského výzkumu, FN v Hradci Králové ; Katedra toxikologie a vojenské farmacie, Fakulta vojenského zdravotnictví v Hradci Králové, Univerzita obrany, Brno
Published in the journal: Cesk Slov Neurol N 2017; 80/113(2): 164-171
Category: Review Article
doi: https://doi.org/10.14735/amcsnn2017164

Práce vznikla za podpory Projektu rozvoje organizace 1011 – DZRO ZHN (Ministerstvo obrany, Česká republika) a RVO – FNHK 00179906 (Ministerstvo zdravotnictví, Česká republika).

Summary

Although intoxication with organophosphates have occurred rather sporadically in the Czech Republic, self-poisoning with organophosphates may represent a serious clinical issue in rural regions of the developing world. According to an estimation from the World Health Organization, up to two million people are poisoned every year. Medical management is usually difficult, associated with the mortality rate of above 15%. Based on chemical-physical properties, the central nervous system is one of the most important targets for organophosphates. Brain damage is defined as a progressive damage resulting from cholinergic neuronal excitotoxicity and dysfunction of the brain cholinergic regions. Loss of neurons, damage to cholinergic and non-cholinergic pathways and degeneration of axons is usually observed in the central nervous system. This delayed secondary neuronal damage might be largely responsible for persistent neuropsychiatric and neurological impairments, such as cognitive, motor and sensory deficits.

Key words:
acetylcholinesterase – pesticides – central nervous system – neuron degeneration – NMDA receptor – cholinergic system

The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manuscript met the ICMJE “uniform requirements” for biomedical papers.

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