Inhibitors of 5-Lipoxygenase
INHIBÍTORY 5-LIPOXYGENÁZY
Leukotriény sú silné mediátory zápalových procesov v organizme. Možnosti inhibície ich biosyntézy bolí intenzívne študované s cielom vyvinút nové spósoby terapie zápalových ochorení, zvlášt astmy. Biosyntéza všetkých leukotriénov je závislá na tvorbe klúčového medziproduktu LTA4, Enzým 5-lipoxygenáza v súčinnosti s FLAP, katalyzuje premenu kyseliny arachidonovej na LTA4, V práci sa diskutuje súčasný vývoj nových liečiv v tejto oblasti terapie.
Klíčová slova:
leukotriény - 5-lipoxygenáza - inhibítory biosyntézy leukotriénov - zileuton
Authors:
M. Gápovský; M. Remko
Authors‘ workplace:
Katedra farmaceutickej chémie Farmaceutickej fakulty Univerzity Komenského, Bratislava
Published in:
Čes. slov. Farm., 2002; , 55-62
Category:
Overview
Leukotrienes are powerfizl mediators of inflammation processes. Possibilities of their biosynthesis inhibition have been intensively studied during recent two decades aiming to develop new methods of therapy of various inflammatory diseases, particularly asthma. Biosynthesis of all leukotrienes is dependent on the production of the key intermediate LTA4, Transformation of arachidonic acid to LTA4 is catalyzed by the enzyme 5-lipoxygenase and faciliated by FLAP. The present paper discusses the results of recent development of new drugs in this area.
Key words:
leukotrienes - 5-lipoxygenase - inhibition of leukotriene synthesis - zileuton
Labels
Pharmacy Clinical pharmacologyArticle was published in
Czech and Slovak Pharmacy
2002 Issue 2
Most read in this issue
- The ACE Inhibitor Captopril in the Light of Recent Clinical Studies
- Inhibitors of 5-Lipoxygenase
- Effects of Consupren, Carvedilol and BL-443 on Lactate Dehydrogenase Pattern in Tissues of Rats with Cyclosporine Nephropathy
- Validation of a HPLC Method for the Determination of Dioxopromethazine and Phenylephrine in Eye Drops