Study of local anaesthetics – Part 194 Evaluation of carbopol hydrogels with lidocaine
Authors:
Zuzana Vitková 1; Petra Herdová 1; Jozef Čižmárik 2; Marián Žabka 1; Bronislava Brázdovičová 1; Katarína Bočkajová 1
Authors place of work:
Univerzita Komenského Bratislava, Farmaceutická fakulta, Katedra galenickej farmácie
1; Univerzita Komenského Bratislava, Farmaceutická fakulta, Katedra farmaceutickej chémie
2
Published in the journal:
Čes. slov. Farm., 2011; 60, 79-83
Category:
Original Articles
Summary
The objective of this article is to describe the formulation and evaluation of dermal semisolid drugs – carbopol hydrogels containing the solution of Bukofit, zinc chloride and the local anaestethic lidocaine. The hydrogels were evaluated after 2, 7, 14 and 28 days after their preparation and stored at the temperature of 5 °C ± 0.2 °C. All prepared hydrogels were found to be stable with respect to pH values and rheological parameters. It follows from the found rheological parameters and flow curves that all evaluated hydrogels belong to non-Newtonian thixotropic systems. The extensometric analyses revealed increased deformation values, indicating that the gels can be easily spread out over the mucous membrane which results in the increased ability of the drug to diffuse into it. Based on the results obtained, it can be concluded that the prepared hydrogels have appropriate technological parameters and therefore in the future they may become potential drugs for the treatment of various inflammations in the oral cavity.
Key words:
hydrogel – Bukofit – lidocaine – rheological parameters
Zdroje
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Štítky
Pharmacy Clinical pharmacologyČlánok vyšiel v časopise
Czech and Slovak Pharmacy
2011 Číslo 2
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