Study of local anaesthetics – Part 200
Choice of the optimal type of chitosan for the formulation of local anaesthetics of the carbamate type into hydrogels

Česká verzia

Authors: Jozef Čižmárik ¹; Zuzana Vitková ²; Petra Herdová ²
Authors place of work: Katedra farmaceutickej chémie, Farmaceutická fakulta, Univerzita Komenského, Bratislava ¹; Katedra galenickej farmácie, Farmaceutická fakulta UK, Bratislava ²
Published in the journal: Čes. slov. Farm., 2012; 61, 285-287
Category: Short News

*Venované 60. výročiu založenia Farmaceutickej fakulty Univerzity Komenského v Bratislave.

Summary

The aim of this examination was a study of hydrogels on the base of various types of the natural polymer chitosan with an assay of local anaesthetics of the carbamate type. The concentration of the gel-creating compound in hydrogels was 2.5%. The study included heptacainiumchloride (HEP), pentacainiumchloride (PEN) and carbisocainiumchloride (CAR). Evaluation was focused on the flow properties of prepared gels and the liberation of drugs from them. Based on the achieved results, the optimal type of biopolymer was determined: PEN – CHIT B, for CAR – CHIT C, while in the case of HEP it was found that chitosan is not suitable as a gel-creating base.

Keywords:
heptacaine • pentacaine • carbisocaine • biopolymer • liberation

Received 18 Octobec 2012 / Accepted 26 November 2012

Zdroje

1. Majeti N.V., Kumar R. A review of chitin and chitosan applications. React. Polym. 2000; 46, 1–27.

2. Dasha M., Chiellini F., Ottenbriteb R. M., Chiellini E. Chitosan – a versatile semi-synthetic polymer in biomedical applications. Prog. Polym. Sci. 2011; 36, 981–1014.

3. Rinaudo M. Chitin and chitosan: Properties and applications. Prog. Polym. Sci., 2006; 31, 603–632.