Determination of varenicline in the preparation Champix® with the use of two-dimensional capillary electrophoresis in connection with UV detection
Authors:
Juraj Piešťanský; Katarína Maráková; Lucia Veizerová; Jaroslav Galba; Peter Mikuš
Authors place of work:
Bratislava, Slovenská republika
; Katedra farmaceutickej analýzy a nukleárnej farmácie FaF UK
Published in the journal:
Čes. slov. Farm., 2013; 62, 270-275
Category:
Original Articles
Summary
This paper deals with an analytical method based on two dimensional capillary electrophoresis (CITP-CZE coupling) with simple UV-detection for the determination of a highly effective drug – varenicline. The method was elaborated with the possibility of its future connection with an advanced detection ending – mass spectrometry. The electrolytes for the CITP (LE = 10 mM NH4Ac + 5 mM HAc + 0,05% m-HEC; TE = 10 mM HAc) and CZE (BGE = 20 mM HAc) separation of varenicline were selected considering such requirements. The UV detector was set at the constant wavelength of 237 nm. The presented CITP-CZE-UV combination enabled rapid and effective evaluation of varenicline in the dosage forms with LOD 5.92 ng/ml.
Keywords:
nicotine, varenicline, two dimensional capillary electrophoresis, dosage forms, pharmacy
Zdroje
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Štítky
Pharmacy Clinical pharmacologyČlánok vyšiel v časopise
Czech and Slovak Pharmacy
2013 Číslo 6
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