Primary Hypertension in Childhood

Česká verzia

Authors: H. Hrstková ¹; B. Fišer ²; K. Krontorádová ¹; N. Honzíková ²
Authors place of work: I. dětská interní klinika, Lékařská fakulta Masarykovy univerzity a Fakultní nemocnice Brno přednostka prof. MUDr. H. Hrstková, CSc. ¹; Fyziologický ústav, Lékařská fakulta Masarykovy univerzity, Brno vedoucí prof. MUDr. B. Fišer, CSc. ²
Published in the journal: Čes-slov Pediat 2008; 63 (10): 587-590.
Category: Review

Summary

Some years ago authors started research on primary hypertension in children and adolescents, which has brought new information about the development of primary hypertension. They have been using 24-hour blood pressure monitoring and baroreflex sensitivity determination (BRS in ms/mmHg and BRSf in mHz/mmHg) in all our studies. They found BRS lower than 3.9 ms/mmHg in 5 % of healthy subjects. This value approaches the critical value for the risk of sudden cardiac death in patients after myocardial infarction and corresponds to the value present in hypertensive patients. A decreased BRS and BRSf were found not only in children with hypertension, but also in those with white-coat hypertension.

This is in accordance with a single interpretation. The decrease of BRS/BRSf precedes a pathological blood-pressure increase. Authors also studied the contribution of obesity and BRS/BRSf to the development of hypertension in adolescents. Both factors reach a sensitivity and specificity between 60 % and 65 %, but there is no correlation between the values of body mass index and BRS either in the group of hypertensive patients or in healthy controls. If a ROC (receiver operating curve) is plotted for both values together using logistic regression analysis, sensitivity higher than 70 % and specificity over 80 % are reached. This means that low baroreflex sensitivity is an independent risk factor for the development of primary hypertension. Our studies demonstrate that adolescents with increased blood pressure and with BRS under 7 ms/mmHg should be given care and intensively motivated to change their lifestyle including a change in diet and increase in physical activity.

Key words:
hypertension, baroreflex sensitivity, ambulatory blood pressure monitoring, obesity

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