Endothelial dysfunction in children with Crohn´s disease – a combined diagnostic approach
Authors:
A. Masopustová 1; P. Jehlička 1; J. Sýkora 1; M. Huml 1; J. Schwarz 1; L. Trefil 2
Authors place of work:
Dětská klinika FN, Univerzita Karlova v Praze, Lékařská fakulta v Plzni
přednosta prof. MUDr. J. Sýkora, Ph. D.
1; Ústav klinické biochemie a hematologie FN, Univerzita Karlova v Praze, Lékařská fakulta v Plzni
přednosta prof. MUDr. J. Racek, DrSc.
2
Published in the journal:
Čes-slov Pediat 2015; 70 (1): 3-8.
Category:
Original Papers
Summary
Inflammatory bowel disease (IBD) is associated with a higher risk of cardiovascular disorders in adults, although there are still very sporadic published data in children. The objective of our prospective study was to evaluate endothelial dysfunction (ED) by reactive hyperaemia index (RHI) and specific biochemical parameters in children with Crohn´s disease (CD).
21 CD patients and 12 healthy children were enrolled in the study. Diagnosis of CD was based on clinical, endoscopic and histological criteria including the Paediatric Crohn´s disease Activity Index (PCDAI). ED was assessed using the combination of RHI and specific biochemical markers.
We found significantly lower RHI values in CD patients in comparison to the healthy controls (p<0,05). E-selectin (p<0.05), asymmetric dimethylarginine (p<0.01) and high-sensitive CRP (p<0.05) were significantly increased in CD patients compared to the control group.
Our results demonstrate that Crohn´s disease might be associated with ED and therefore with a higher risk of development of premature atherosclerosis. We also demonstrated the suitability of using the combination of RHI and specific biochemical markers in assessing ED and stratifying of cardiovascular risk and long term follow-up in children with CD.
Key words:
endothelial dysfunction, children, reactive hyperaemia index, asymmetric dimethylarginine, Crohn´s disease
Zdroje
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Štítky
Neonatology Paediatrics General practitioner for children and adolescentsČlánok vyšiel v časopise
Czech-Slovak Pediatrics
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