Adipocytokines as possible etiopathogenetic mechanisms leading to a higher incidence of autoimmune thyroiditis in patients with type 2 diabetes mellitus

Česká verzia

Authors: Štefan Sotak ¹; Zbynek Schroner ²; Ivica Lazúrová ¹; Marek Felš Ci ¹; Darina Petrášová ³; Izabela Bertková ⁴; Miriam Mitníková ⁵; Jozefína Petrovičová ⁶
Authors place of work: I. interná klinika LF UPJŠ a UNLP Košice ¹; IV. interná klinika LF UPJŠ a UNLP Košice ²; Laboratórium výskumných biomodelov LF UPJŠ v Košiciach ³; Ústav experimentálnej medicíny LF UPJŠ v Košiciach ⁴; Oddelenie laboratórnej medicíny UNLP Košice ⁵; Ústav lekárskej informatiky LF UPJŠ v Košiciach ⁶
Published in the journal: Diab Obez 2019; 19(38): 103-109
Category: Reviews

Summary

Introduction: Autoimmune thyroiditis (AIT) and type 2 diabetes mellitus (DM) are the most common endocrinological diseases worldwide. Relationship between type 1 DM and AIT is well-known and described. Relation between these diseases explains several hypotheses. One of them is influence of some adipocytokines.

Objective: This study evaluated relationship between three adipocytokines (adiponectin, resistin, visfatin) and thyroidal status in patients with type 2 DM and AIT compared to control group (CG).

Material and methods: The group consisted of four subgroups: patients with type 2 DM without thyreopathies (n = 45), patients with AIT on substitution therapy without diabetes and prediabetes (n = 37), patients with type 2 DM and AIT on substitution therapy (n = 28) and healthy subjects as a CG (n = 34). We investigated parameters of thyroid and glycid metabolism and levels of three adipocytokines by venous blood-letting.

Results: We did not find statistically significant differences of adiponectine, resistin and visfatin levels between individual groups. We found moderate negative correlation between visfatin and fasting glucose levels (r = -0.35, p = 0.03) in patients with AIT without type 2. Conclusion: Our results are consistent with several studies, which do not find any relationship between thyropathies and adipocytokines.

Keywords:

adipocytokines – Adiponectin – autoimmune thyroiditis – resistin – type 2 diabetes mellitus – visfatin

Zdroje

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