The renal and cardiovascular results of the CREDENCE study: implications for the clinical practice

Česká verzia

Authors: Zbynek Schroner
Authors place of work: SchronerMED s. r. o., Košice
Published in the journal: Diab Obez 2019; 19(38): 118-120
Category: Clinical studies

Summary

CREDENCE (Canagliflozin in Renal Events in Diabetes with Established Nephropathy) was randomized, double-blind, placebo-controlled study with the aim assessing effect of SGLT2 inhibitor – canagliflozin 100 mg in comparison with placebo on renal outcomes in patients with diabetic nephropathy in chronic kidney disease (CKD) stages 2–3b. Before randomisation all patients had to be treated with the renin-angiotensin system blocker in order to find out add-on effect of canagliflozin on progression of CKD. Canagliflozin reduced risk of primary renal outcome (doubling of the serum creatinine level, end-stage kidney disease, death from renal or cardiovascular /CV/ causes) by 30 % s placebo. Canagliflozin vs placebo also decreased some secondary outcomes, composit CV outcome (CV mortality, nonfatal myocardial infarction and stroke) by 20 %. There were no significant differences in rate of amputations or fractures between canagliflozin vs placebo.

Keywords:

canagliflozin – diabetic nephropathy – study CREDENCE – type 2 diabetes treatment

Zdroje

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