Recent view on the pathophysiology and pharmacotherapy of the depressive disorder
Současný pohled na patofyziologii a léčbu depresivní poruchy
Autor shrnuje základní znalosti z posledních desetiletí a jejich vývoj týkající se teorií patofyziologie depresivní poruchy a hypotéz o mechanismu účinku antidepresiv, počínaje hypotézami deplece významných neurotransmiterů až po současné teorie o významu neuroplasticity.
Klíčová slova:
deprese – patofyziologie – antidepresiva – léčba – neurotransmitery– noradrenalin – serotonin – inhibitory zpětného vychytávání – inhibitory MAO – hypersenzitivita receptoru – neuroplasticita – CREB – BDNF.
Authors:
R. Honzák
Authors‘ workplace:
Ústav všeobecného lékařství 1. LF UK, Praha
přednosta MUDr. B. Seifert
; Psychiatrická ambulance IKEM, Praha
ředitel prof. ing. R. Poledne, CSc.
; Katedra psychiatrie IPVZ, Praha, vedoucí prof. MUDr. K. Chromý, CSc.
Published in:
Prakt. Lék. 2005; 85(10): 551-555
Category:
Various Specialization
Overview
The submitted article comprises the basic knowledge dealing with pathophysiological theories of depression and with hypotheses on the mechanism of pharmacological action of antidepressant drugs and their development over the last several decades: from depletion hypotheses to the theory of neuroplasticity.
Key words:
depression – pathophysiology – antidepressants – therapy – neurotransmitters – noradrenaline – serotonin – reuptake inhibitors – MAO inhibitors – receptor hypersensitivity – neuroplasticity – CREB – BDNF.
Labels
General practitioner for children and adolescents General practitioner for adultsArticle was published in
General Practitioner
2005 Issue 10
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