Primary extragonadal germ cell tumours in men - analysis of patients treated from 1994 to 2008 in a single institution.
Authors:
T. Büchler; M. Foldyna; J. Nepomucká; M. Kupec; Z. Donátová; P. Kubánková; E. Voršilková; D. Kordíková; J. Mendelová; J. Abrahámová
Authors place of work:
Fakultní Thomayerova nemocnice a 1. lékařská fakulta Univerzity Karlovy, Praha
; Primář: Prof. MUDr. Jitka Abrahámová, DrSc.
; Onkologické oddělení
Published in the journal:
Prakt. Lék. 2008; 88(10): 578-581
Category:
Of different specialties
Summary
Patients with extragonadal germ cell tumours have poor prognosis because of the relative chemoresistance of these tumours and often advanced stage with multiple organ dissemination at diagnosis. The optimal treatment strategy for extragonadal germ cell tumours is unclear. We have retrospectively analysed 19 men with germ cell tumours originating in the mediastinum or the retroperitoneum. Median overall survival of our patients was 25.9 months. Seven of the 19 patients (37 %) are alive, including 2 who are still undergoing treatment and 5 (26 %) who are alive and free of disease. Our results imply that, despite worse prognosis of these patients as compared to the outcome in patients with a testicular primary, long-term disease-free survival is possible even if complete remission is not achieved by first-line treatment.
Key words:
extragonadal, germ cell, tumour, chemotherapy.
Zdroje
1. Abrahámová, J. Extragonadální germinální nádory. In: Abrahámová J., Povýšil C., Dušek L. a kol. Nádory varlat. Praha: Grada 2008.
2. Oosterhuis, J.W., Stoop, H., Honecker, F., Looijenga, L.H. Why human extragonadal germ cell tumours occur in the midline of the body: old concepts, new perspectives. Int. J. Androl. 2007, 30, 4, p. 256-263.
3. Bokemeyer, C., Nichols, C.R., Droz, J.P. et al. Extragonadal germ cell tumors of the mediastinum and retroperitoneum: results from an international analysis. J. Clin. Oncol. 2002, 20, 7, p. 1864-1873.
4. Hartmann, J.T., Nichols, C.R., Droz, J.P. et al. Prognostic variables for response and outcome in patients with extragonadal germ-cell tumors. Ann. Oncol. 2002, 13, 7, p. 1017-1128.
5. Daugaard, G., Rørth, M., von der Maase, H., Skakkebaek, N.E. Management of extragonadal germ-cell tumors and the significance of bilateral testicular biopsies. Ann. Oncol. 1992, 3, 4, p. 283-289.
6. Buchler, T., Freeman, A., Harland, S. Contralateral intratubular germ cell neoplasia in a patient with testicular cancer. Nat. Clin. Pract. Urol 2008, 5, 5, p. 284-288.
7. International Germ Cell Cancer Collaborative Group. International Germ Cell Consensus Classification: a prognostic factor-based staging system for metastatic germ cell cancers. J. Clin. Oncol. 1997, 15, 2, p. 594-603.
8. Hsu, Y.J., Pai, L., Chen, Y.C. et al. Extragonadal germ cell tumors in Taiwan: an analysis of treatment results of 59 patients. Cancer 2002, 95, 4, p. 766-774.
9. Kumano, M., Miyake, H., Hara, I. et al. First-line high-dose chemotherapy combined with peripheral blood stem cell transplantation for patients with advanced extragonadal germ cell tumors. Int. J. Urol. 2007, 14, 4, p. 336-338.
10. De Giorgi, U., Demirer, T., Wandt, H. et al. Second-line high-dose chemotherapy in patients with mediastinal and retroperitoneal primary non-seminomatous germ cell tumors: the EBMT experience. Ann. Oncol. 2005, 16, 1, p.146-151.
11. De Santis, M., Pont, J. The role of positron emission tomography in germ cell cancer. World J. Urol. 2004, 22, 1, p. 41-46.
12. Karapetis, C.S., Strickland, A.H., Yip, D. et al. Use of fluorodeoxyglucose positron emission tomography scans in patients with advanced germ cell tumour following chemotherapy: single-centre experience with long-term follow up. Intern. Med. J. 2003, 33, 9-10, p. 427-435.
13. Bokemeyer, C., Kollmannsberger, C., Oechsle, K. et al. Early prediction of treatment response to high-dose salvage chemotherapy in patients with relapsed germ cell cancer using [(18)F]FDG PET. Br. J. Cancer 2002, 86, 4, p. 506-511.
14. Hain, S.F. Positron emission tomography in uro-oncology. Cancer Imaging 2005, 5, 1, p. 1-7.
Štítky
General practitioner for children and adolescents General practitioner for adultsČlánok vyšiel v časopise
General Practitioner
2008 Číslo 10
- Advances in the Treatment of Myasthenia Gravis on the Horizon
- Memantine Eases Daily Life for Patients and Caregivers
- What Effect Can Be Expected from Limosilactobacillus reuteri in Mucositis and Peri-Implantitis?
- Spasmolytic Effect of Metamizole
- Metamizole at a Glance and in Practice – Effective Non-Opioid Analgesic for All Ages
Najčítanejšie v tomto čísle
- Guillain-Barré syndrome. Specific features of intensive care, potential for therapeutic use of plasmapheresis, and our experience
- Common basic classifications of child fractures
- Mentalization
- Uncommon nasopharyngeal tumor in old age - nasopharyngeal angiofibroma?