Early cancerogenesis in head and neck squamous cell carcinoma

Česká verzia

Authors: J. Kastner ¹; J. Bouček ^1,2; J. Betka ^1,2; J. Plzák ^1,3,4; M. Jáchymová ⁵; J. Betka ¹
Authors place of work: Klinika otorhinolaryngologie a chirurgie hlavy a krku 1. LF UK a FN v Motole, Katedra otorhinolaryngologie IPVZ, Praha Přednosta: Prof. MUDr. Jan Betka, DrSc. ¹; Mikrobiologický ústav AV ČR, Sektor Imunologie a gnotobiologie, Praha Vedoucí: Prof. RNDr. Blanka Říhová, DrSc. ²; Anatomický ústav 1. LF UK, Praha Přednosta: Prof. MUDr. Miloš Grim, DrSc. ³; Centrum buněčné terapie a tkáňových náhrad 2. LF UK, Praha Vedoucí: Prof. MUDr. Eva Syková, DrSc. ⁴; Ústav klinické biochemie a laboratorní diagnostiky 1. LF UK a VFN, Praha Přednosta: Prof. MUDr. Tomáš Zima, DrSc., MBA. ⁵
Published in the journal: Prakt. Lék. 2008; 88(9): 501-505
Category: Reviews

Summary

Squamous cell carcinoma is the most frequent malignant tumour of the head and neck. It affects more than one thousand patients in the Czech Republic each year. Despite advances in surgical techniques (endoscopic surgery, functional neck dissection etc.), instruments (laser, harmonic ultrascission knife, radiofrequency a.o.) and oncology guidelines, the overall 5-year survival rate remains under 50 %. The article reviews current data on early cancerogenesis of head and neck squamous cell carcinoma and outlines possible research trends.

Key words:
head and neck squamous cell carcinoma, tailored medicine, molecular biology, field cancerization, biochip, RT-PCR.

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