Prevention of inflammatory complications of cataract operations – results of a clinical trial of levofloxacin topical use

Česká verzia

Authors: N. Jirásková; P. Rozsíval; M. Burova; M. Kalfeřtová
Authors place of work: Přednosta: prof. MUDr. Pavel Rozsíval, CSc. ; Lékařská fakulta a Fakultní nemocnice v Hradci Králové ; Oční klinika ; Univerzita Karlova, Praha
Published in the journal: Prakt. Lék. 2010; 90(5): 300-301
Category: Of different specialties

Summary

The authors report the outcome of a clinical study on the topical use of a broad-spectrum antibiotic (levofloxacin) in the prophylaxis of post-operative endophthalmitis. One hundred and four eyes (of 104 patients) that underwent cataract surgery at the Department of Ophthalmology of the University Hospital, Hradec Kralove, were studied. No peri- or postoperative complications were observed, there was no case of postoperative endophthalmitis in this group and topical levofloxacin was well tolerated by all patients without any allergic reaction. Based on our results we recommend the topical use of levofloxacin 0.5 % drops in combination with steroids for the prevention of post-operative endophthalmitis.

Key words:
cataract surgery, intraocular inflammation, levofloxacin.

Zdroje

1. Barry, P., Seal, D. V., Gettinby, G. et al. ESCRS study of prophylaxis of post-operative endophthalmitis after cataract surgery: Preliminary report of principal results from a European multi-centre study. J. Cataract. Refract. Surg. 2006, 32, p. 407-410.

2. ESCRS Endophthalmitis Study Group. Prophylaxis of post-operative endophthalmitis following cataract surgery: results of the ESCRS multi-centre study and identification of risk factors. J. Cataract. Refract. Surg. 2007, 33, p. 978-988.

3. Healy, D.P., Holland, E.J., Nordlund, M.L. et al. Concentrations of levofloxacin, ofloxacin and ciprofloxacin in human corneal stromal tissue and aqueous humor after topical administration. Cornea 2004, 23, p. 255-263.

4. Kadlecová, J., Jirásková, N., Rozsíval, P. Význam operace katarakty pro pacienty starší osmdesáti let. Prakt. Lék., 2006, 86, s. 265-267.

5. Nekolová, J., Jirásková, N., Rozsíval, P. Hodnocení opacit zadního pouzdra u pacientů 7 let po operaci katarakty. Oftalmochirurgie 2005, 1(4), s. 25-37.

6. Koch, H.-R., Kulus, S.C., Roessler, M. et al. Corneal penetration of fluoroquinolones: aqueous humour concentrations after topical application of levofloxacin 0.5% and ofloxacin 0.3% eyedrops. J. Cataract. Refract. Surg. 2005, 31, p. 1377-1385.

7. Raizman, M.B., Rubin, J.M., Graves, A. L., Rinehart, M. Tear concentrations of levofloxacin following topical administration of a single dose of 0.5% levofloxacin ophthalmic solution in healthy volunteers. Clin. Ther. 2002, 24(9), p. 1439-1450.

8. Seal, D.V., Bary, P., Gettinby, G. et al. ESCRS study of prophylaxis of post-operative endophthalmitis after cataract surgery: Case for a European multi-centre study. J. Cataract. Refract. Surg. 2006, 32, p. 396-406.